摘要
[目的]探讨果蝇zeste基因增强子同源物2(EZH2)和脆性组氨酸三联体(FHIT)蛋白在原发性肝细胞性肝癌(HCC)组织中的表达,及其在肝癌发生发展过程中的作用和临床病理学意义。[方法]应用免疫组化S-P法检测50例原发性肝细胞性肝癌、30例肝硬化、10例正常肝组织中EZH2、FHIT蛋白的表达。[结果]FHIT蛋白在HCC中的表达明显低于肝硬化和正常肝组织,阳性表达率分别是40.00%(20/50)、80.00%(24/30)、80.00%(8/10),三者之间具有明显的差异性(χ2=15.74,P<0.05);HCC、肝硬化和正常肝组织中EZH2蛋白阳性表达率分别是88.00%(44/50)、46.67%(14/30)、30.00%(3/10),三者之间的差异有统计学意义(χ2=20.63,P<0.05),且EZH2蛋白在HCC组织中的表达明显高于肝硬化和正常肝组织中的表达(χ2=16.07,χ2=14.07,P均<0.05)。[结论]EZH2蛋白在肝癌中的表达增加与FHIT蛋白相关,提示肝癌中EZH2蛋白与FHIT蛋白可能相互协调,促进肝癌的发生发展。
[Purpose] To explore the expressions of EZH2 and FHIT protein in primary human hepatocellular carcinoma（HCC）and their clinicopathological significance. [Methods] The expressions of EZH2 and FHIT protein in 50 cases with HCC,30 cases with liver cirrhosis and 10 cases with normal liver tissues were assessed by immunohistochemical S-P method. [Results] The expression of FHIT protein in cancer tissues was lower than that in cirrhosis tissues and normal tissues,and the positive rates were 40.00%（20/50）,80.00%（24/30）,80.00%（8/10）respectively,with significant difference（χ2=15.74,P0.05）;The positive rates of EZH2 protein in cancer tissues,cirrhosis tissues,normal tissues were 88.00%（44/50）,46.67%（14/30）,30.00%（3/10）respectively,also with significant difference（χ2=20.63,P0.05）.The expression of EZH2 protein in cancer tissues was higher than that in cirrhosis tissues and normal tissues（χ2=16.07,χ2=14.07,P0.05）. [Conclusion] The increased expression of EZH2 protein is closely associated with FHIT protein in HCC; EZH2 and FHIT protein may have mutual coordination to promote HCC development.
出处
《肿瘤学杂志》
CAS
2013年第7期514-517,共4页
Journal of Chinese Oncology
