摘要
目的探讨CT引导下经皮穿刺^125I粒子植入治疗晚期肺癌的可行性、疗效及并发症情况。方法根据治疗方法的不同，将65例晚期肺癌患者分为2组，单纯植入粒子组37例，行单纯CT引导下^125I粒子植入治疗；联合组28例，行^125I粒子植入治疗联合泽菲和顺铂化疗，两组患者术后均行剂量学验证，并定期随访复查。结果65例患者术后总有效率为80．0％，1年生存率为90．8％，单纯植入粒子组与联合组的有效率分别为67．6％和96．4％，两组之间差异有统计学意义（X^2=8．298，P〈0．01）。所有患者治疗前肿瘤平均直径为5．48cm，治疗后为3．77cm，治疗前、后差异有统计学意义（t=7．764，P〈0．01）。65例患者术后36例出现气胸，7例出现血痰，4例出现发热，对症处理后均好转；未出现放射性肺炎等。结论^125I粒子植入治疗晚期肺癌的近期疗效肯定，无严重并发症。
Objective To investigate the feasibility, efficacy and complications of CT guided radio-active ^125I seed implantation in the treatment of lung cancer. Methods According to the different treatment methods, 65 patients with lung cancer were divided into two groups, 37 cases in the implantation alone group received CT guided ^125I seeds interstitial implantation, the other 28 cases in the combination treatment group received interstitial ^125I seeds implantation combined with chemotherapy. All the patients were exam-ined by posologic validation, and were followed up termly. Results The total effictive rate of 65 patients was 80.0%, 1-year survival rate was 90.8%. The effietive rates of implantation alone group and combination treatment group were 67.6% and 96.4% respectively. There was a significant difference between the two groups （X^2=8.298, P〈0.01 ）. Before treatment, all the patients＇ mean diameter of the tumor was 5.48 cm; while it was 3.77 cm after treatment （t=7.764, P〈0.01 ）. Complications included pneumothorax （36 cases）, bloody sputum （7 cases ）, fever （4 cases ） which improved after treatment in 65 patients, but without radiation pneumonia. Conclusion ^125I seed implantation is a highly effective treatment without severe complications in the treatment of lung cancer.
出处
《国际放射医学核医学杂志》
2013年第4期203-206,共4页
International Journal of Radiation Medicine and Nuclear Medicine
