摘要
目的:分析支原体肺炎患儿血清IL-2、IL-8、TNF-α表达情况。方法:选择2010年1月-2013年1月笔者所在医院收治的40例支原体肺炎患儿(观察组)和同期健康体检儿童40例(对照组),分别检测其血清IL-2、IL-8、TNF-α和免疫球蛋白水平。结果:急性期患儿IL-2显著小于恢复期患儿和对照组患儿(P<0.05),IL-8和TNF-α显著大于恢复期患儿和对照组患儿(P<0.05),但是恢复期患儿的IL-2、IL-8和TNF-α与对照组比较差异均无统计学意义(P>0.05)。观察组患者免疫球蛋白与对照组比较,差异无统计学意义(P>0.05)。结论:IL-2、IL-8、TNF-α共同参与了支原体肺炎的发生、发展过程,联合检测这些细胞因子的血清水平有助于判断支原体肺炎病情的严重程度。
Objective： To analyze the levels of IL-2, IL-8 and TNF- a in children with mycoplasma pneumonia.Methods： Selecting 40 cases of children with mycoplasma pneumonia and 40 cases healthy check-up children in our hospital from Jan 2010 to Jan 2013.Then detecting the serum levels of IL-2, IL-8, TNF- α and immunoglobulin.Results： The level of IL-2 at acute stage was significantly lower than that at recovery phase and control group（P〈0.05）.The levels of IL-8 and TNF- α at acute stage were significantly higher than those at recovery phase and control group（P〈0.05）.However, the levels of IL-2, IL-8 and TNF- α at acute stage were not significantly different with control group（P〉0.05）.There was no significant difference in immune globulin between groups（P〉O.OS）.Condusion： IL-2, IL-8 and TNF- α may play an important role in the pathogenesis of mycoplasma pneumonia.Joint detection of the serum level of cytokines help determine mycoplasma pneumonia severity of the illness.
出处
《中外医学研究》
2013年第22期78-79,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
