摘要
目的：观察法舒地尔对慢性心力衰竭（CHF）的临床疗效及血浆脑钠肽（BNP）的影响。方法：将100例心功能（NYHA）Ⅲ~Ⅳ级冠心病慢性心力衰竭患者随机分为治疗组和对照组,各50例。两组均给予常规治疗：利尿剂、口服血管紧张素转换酶抑制剂、地高辛等,治疗组在此治疗基础上静脉滴注法舒地尔60mg/d,治疗前后观察两组患者血浆脑钠肽浓度变化及采用超声心动图、6min步行实验等方法进行疗效观察。结果：两组治疗后BNP、心功能、6min步行实验距离均明显改善（P〈0.01）,治疗组较对照组更明显,BNP降低显著（398.2±105.3）/（456.5±106.4）ng/L（P〈0.05）,左室射血分数（LVEF）分别为（53.4±9.9）/（46.5±8.3）%,左室射血分数增加明显（P〈0.05）,6min步行距离明显增加（419.2±71.6）/（382.5±53.7）m（P〈0.05）。结论：法舒地尔能有效降低慢性心衰患者血浆BNP,改善心功能。
Objective： To explore the difference of brain natriuretic peptide（BNP） concentration and clinical effects in patients with chronic heart failure who received Fasudil ： One hundred chronic heart failure patients with cardiac function（NYHA） III-IV were randomly divided into the treatment group（n=50） and the control group（n=50）.The two groups were given conventional treatment, including diuretics, oral angiotensin-converting enzyme inhibitors, digoxin.Patients in treatment group on the basis of this treatment were treated with Fasudil 60 mg/d.The plasma levels of BNP was detected, LVEF and CO were observed by echocardiography, and the exercise endurance were eval;aated by 6-minutes walking test before and after the treatment.Results： The plasma levels of BNP, left ventrieular function（LVFF） and the distance of 6-minntes walking test were significantly improved after therapy in two groups（P〈0.01）, especially in the treatment group（P〈0.05）.The concentrations of BNP in treatment group were significantly decreased（398.2 ± 105.3）/（456.5± 106.4）ng/L（P〈0.05）.LVEF of the patients in treatment group were increased significantly（53.4± 9.9）/（46.5± 8.3）%（P〈0.05）.The distance of＇6-minutes walking test of the patients in the treatment group were also significantly increased（419.2 ± 71.6）/（382.5 ± 53.7）m（P〈0.05）.Conclusion： Fasudil can significantly improve cardiac function and decrease plasma BNP level of chronic heart failure patients.
出处
《中外医学研究》
2013年第22期6-8,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
法舒地尔
慢性心力衰竭
脑钠肽
6min步行实验
Fasudil
Chronic heart failure
Brain natriuretic peptide
6-minutes walking test
