摘要
目的:探讨苯妥英钠预防颅内恶性肿瘤患者手术后癫痫的血药浓度与其体内病理生理因素及合并用药的相关性,为临床合理使用苯妥英钠提供参考。方法:收集133例次颅内肿瘤患者手术后使用苯妥英钠预防癫痫的病历资料,记录患者性别、年龄、体质量、血药浓度、CYP2C9和CYP2C19基因多态性,以及相应生化检验值。应用SAS软件(6.04&8.0版)对数据进行多元线性回归分析。结果:苯妥英钠血药浓度与年龄和体质量之间存在明显正相关性(P<0.05),但与CYP2C9基因多态性呈明显负相关性(P<0.05)。结论:应主要从患者年龄、体质量以及CYP2C9基因多态性的角度,设计苯妥英钠的个体化剂量方案。
OBJECTIVE：To investigate the relation between blood concentration of phenytoin sodium and patho-physiological factors and drug combination in patients with intracranial malignant tumor after surgery,and to provide reference for rational use of phenytoin sodium in the clinic.METHODS：Blood concentration of phenytoin sodium and clinical information data such as gender,age,body weight,gene polymorphisms of CYP2C9 and CYP2C19,the corresponding biochemical testing results were collected from 133 patients with intracranial malignant tumor after surgery and analyzed with multiple linear regression method by using SAS software（6.04 ＆ 8.0 edition）.RESULTS：Significant positive relation was found between blood concentration of phenytoin sodium and age or body weight（P＆lt;0.05）,but significant negative relation was found between blood concentration of phenytoin sodium and gene polymorphisms of CYP2C9（P＆lt;0.05）.CONCLUSIONS：Individual dosage regimen may be designed according to patient’s age,body weight and gene polymorphisms of CYP2C9.
出处
《中国药房》
CAS
CSCD
2013年第30期2824-2826,共3页
China Pharmacy
基金
首都医学发展科研基金资助(No.2009-2055)
关键词
苯妥英钠
血药浓度
多元线性回归
Phenytoin sodium
Blood concentration
Multiple linear regression
