摘要
重度新生儿HIE可以导致新生儿死亡及儿童脑性瘫痪、智力落后、癫痫等神经系统后遗症，目前尚无根治性措施。干细胞移植疗法为其带来了新的希望。其中，脐带间充质干细胞具有来源丰富、容易提取、倍增时间短、免疫原性低、移植后长时间存活等多种优点，作为治疗新生儿HIE的细胞来源有着广泛的应用前景。
Severe neonatal hypoxic-ischemic encephalopathy （HIE）can result in serious outcomes including death during the newborn period and permanent neuropsychological handicaps in the form of cerebral palsy, learning disability, epilepsy and so on. So far, there have been no effective treatments in clinical practice. Stem cell transplanta- tion therapy brings new hope for HIE treatment. Among them, umbilical cord-derived mesenchymal stem cells have many advantages such as rich source, easy collection, shorter doubling time,lower immunogenicity and long-term survi-val af- ter transplantation,it will have a broad application prospects as a cell source for the treatment of neonatal HIE.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2013年第14期1112-1114,共3页
Chinese Journal of Applied Clinical Pediatrics
关键词
脐带
间充质干细胞
治疗
缺氧缺血性脑病
婴儿
新生
Umbilical cord
Mesenchymal stem cell
Treatment
Hypoxic-ischemic eneephalopathy
Infant, newborn
