摘要
目的检测宫颈癌与正常宫颈组织中Cx32的表达并探讨其临床意义。方法收集正常宫颈组织和宫颈癌标本47例,用免疫组织化学方法检测癌组织和正常组织中Cx32蛋白的表达,并比较Cx32蛋白表达与临床病理参数的关系。结果 Cx32蛋白在宫颈癌组织的表达明显低于正常组织(P<0.05),Cx32蛋白的表达与患者发病年龄、临床分期、肿瘤类型及淋巴结转移无关(P>0.05),但与宫颈癌的分化程度有关(P<0.05)。结论 Cx32与宫颈癌的发生密切相关,并与肿瘤的发展和预后有关。
Objective To detect the expressions of Connexin 32 （CX32） in cervical cancer and normal ：ervical tissues and to explore its clinical significance. Methods Specimens of normal cervical tissues and ：ervical cancer in 47 cases were collected, immunohistochemical methods was used to detect the expres- sions of CX32 protein in carcinoma tissues and normal tissues, and the relationship between CX 32 protein expressions and clinical pathological parameters was compared. Results CX32 expressions of protein in cer- vical cancer tissue was lower than those in normal group （ P 〈0.05）. CX32 protein expressions were was aot associated with the onset age, clinical stage, tumor type and lymph node metastasis （ P 〉0.05）, but was associated with the differentiation degree of cervical cancer （ P 〈 0.05）. Conclusion CX32 is closely ：elated to the occurrence of cervical cancer and is associated with tumor development and prognosis.
出处
《山东医学高等专科学校学报》
2013年第3期167-170,共4页
Journal of Shandong Medical College
基金
山东省高等学校科技计划项目(No:J12LL57)
关键词
CX32
宫颈癌
免疫组化
Connexin 32 Cervical cancer Immunohistochemistry
