摘要
铁过度累积可加重胰岛素抵抗，对2型糖尿病的发生、发展具有推动作用。铁代谢调节机制中涉及铁调素，它是铁代谢的核心调节剂，能抑制铁的吸收和释放。有研究发现，2型糖尿病患者血清铁调素水平较正常人升高，但关于铁调素参与2型糖尿病的机制目前研究甚少。通过对铁调素与2型糖尿病关系的研究发现，在2型糖尿病患者中铁调素与铁蛋白呈正相关。铁调素与糖代谢有关，其可能通过对铁代谢的调节在2型糖尿病中发挥一定作用，从而为2型糖尿病的防治提供新思路。
Excessive accumulation of iron can aggravate insulin resistance, promote the development of type 2 diabetes. Hepcidin is related to iron metabolism regulation, which is a core regulator of iron metabo-lism and can inhibit the absorption and release of iron. Studies have found serum hepcidin levels were higher in type 2 diabetic patients than those in normal people, but the mechanisms of hepcidin involved in type 2 di-abetes are few. It was found that hepcidin was positively correlated with ferritin in type 2 diabetic patients, through studies about the relationship between hepcidin and type 2 diabetes. Hepcidin is related with glucose metabolism, and plays a role in type 2 diabetes through regulating iron metabolism, thereby provides new ide-as for the prevention and treatment of type 2 diabetes.
出处
《国际内分泌代谢杂志》
北大核心
2013年第4期255-257,共3页
International Journal of Endocrinology and Metabolism
关键词
铁调素
铁代谢
2型糖尿病
Hepcidin
Iron metabolism
Type 2 diabetes mellitus
