摘要
目的:观察桂枝茯苓丸联合黄连素对多囊卵巢综合征(PCOS)伴胰岛素抵抗患者的影响。方法:112例PCOS患者随机分为观察组(桂枝茯苓丸联合黄连素)和对照组(达英-35联合二甲双胍),各56例,比较两组患者治疗前后糖代谢、血脂水平、性激素水平的变化,观察临床表现和排卵及妊娠情况。结果:治疗后两组空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)明显下降(P<0.05)。两组空腹血糖(FPG),FINS,HOMA-IR无差异性。观察组患者总胆固醇(TC)、甘油三酯(TG)水平明显下降。两组的高密度脂蛋白(HDL-C)上升明显,尤其观察组HDL-C[(1.91±0.29)mmol.L-1]改善程度较对照组[(1.63±0.28)mmol.L-1]明显(P<0.05)。两组患者雄激素(T)、黄体生成素(LH)、LH/卵泡刺激素(FSH)明显下降,FSH,雌二醇(E2)水平明显上升(P<0.05或0.01)。观察组LH,LH/FSH,E2改善程度较对照组明显(P<0.05),且观察组月经稀发、痤疮、卵巢体积增大改善的程度较对照组明显(P<0.05),排卵率明显高于对照组。结论:桂枝茯苓丸联合黄连素治疗PCOS合胰岛素抵抗的患者,能通过不同途径改变空腹胰岛素和雄激素水平,改善胰岛素敏感度,恢复月经周期,提高妊娠率。
Objective： To observe influence of Guizhi Fuling pill combined with berberine on polycystic ovary syndrome（PCOS） with insulin resistance patients.Method： One hundred and twelve cases with PCOS were randomly divided into observation group（Guizhi Fuling pill combined with berberine） and control group（diane-35 combined with metformin）,glucose metabolism,lipid levels,sex hormone levels,clinical manifestations and ovulation and pregnancy were observed before and after treatment.Result： After the treatment,the level of fasting insulin（FINS）,homeostasis model assessment of insulin resistance（HOMA-IR） was decreased significantly（P 0.05）.Fasting plasma glucose（FPG）,FINS,HOMA-IR between two groups had no difference（P 0.05）.The level of total cholesterol（TC）,triglycerides cholesterol（TG） in observe group were significantly decreased（P 0.05）.High-density lipoprotein cholesterol（HDL-C） in two groups increased significantly,especially degree of HDL-C in observation group was better than that in control grousignificantly（P 0.05）.Luteinizing hormone（LH）,LH / FSH,estriol（E2） in two groups decreased significantly and folliclestimulating hormone（FSH）,E2 increased significantly（P 0.05 or 0.01）.especially The improvement degree of LH,LH / FSH,E2,oligomenorrhea,acne,ovarian volume in observation group was better than those in control group（P 0.05）.Ovulation was significantly higher than that in control group（P 0.05）.Conclusion： Guizhi Fuling pill combined with berberine can decrease insulin resistance,changing the fasting insulin and androgen levels in different ways,improving insulin sensitivity,restoring menstrual cycle,improving the pregnancy rate.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第15期320-323,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
多囊卵巢综合征
桂枝茯苓丸
黄连素
胰岛素
血脂
性激素
polycystic ovary syndrome
Guizhi Fuling pill
berberine
insulin
blood lipid
sex hormone
