摘要
目的:研究阿托伐他汀在冠状动脉慢血流患者中的治疗作用。方法:将72例冠状动脉慢血流患者随机分为阿托伐他汀组(38例)和对照组(34例)。对照组采用拜阿司匹林100mg/d、单硝酸异山梨酯20mg/d、曲美他嗪20mg/d联合治疗,阿托伐他汀组在此基础上加用阿托伐他汀20mg/d治疗。观察治疗前后两组患者冠状动脉TIMI血流分级和冠状动脉血流储备的变化。结果:阿托伐他汀组冠状动脉TIMI血流改善的有效率较对照组明显增高(P<0.05),冠状动脉血流储备值较治疗前明显增高(P<0.05)。对照组冠状动脉血流储备值较治疗前无显著性变化(P>0.05)。结论:长期阿托伐他汀治疗可改善冠状动脉慢血流患者TIMI血流分级和冠状动脉血流储备功能。
Objective：To study the therapeutic effect of atorvastatin on patients with coronary slow flow. Meth- od：The 72 cases with coronary slow flow were randomly divided into the atorvastatin treatment group （n = 38） and control group （n=34）. The control group was treated with aspirin （100 mg/d）, isosorbide mononitrate （20 mg/ d） and trimetazidine（20 mg/d）. The atorvastatin treatment group was treated with atorvastatin on the basis of the routine treatment. The changes of TIMI grade of coronary artery blood flow and coronary flow reserve between two groups were observed before and after treatment. Result：The effective rate on the improvement of TIMI grade of coronary artery blood flow in the treatment group was significantly higher than the control group （P〈0.05）, and the coronary flow reserve values were significantly increased compared with those before treatment （P〈0.05）. The coronary flow reserve values of control group had no significant changes than before treatment （P〉0.05）. Conclusion：The long term atorvastatin therapy may improve the TIMI grade of coronary artery blood flow and coronary flow reserve in the patients with coronary slow flow.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2013年第7期510-512,共3页
Journal of Clinical Cardiology
基金
武汉市卫生局科研项目(No:WX12D06)
关键词
冠心病
阿托伐他汀
冠状动脉造影
冠状动脉血流储备
慢血流
coronary disease
atorvastatin
coronary angiography
coronary flow reserve
coronary slow flowphenomenon
