摘要
目的探讨全胚冷冻后首次行冻融胚胎移植(FET)的临床结局是否优于新鲜胚胎移植。方法回顾性分析本中心2010年1月至2011年12月接受全胚冷冻后行首次FET(165例)与同期行新鲜胚胎移植(1,951例)患者的临床结局。按全胚胎冷冻的原因不同分为6组,即卵巢过度刺激综合征组、孕酮升高组、内膜异常组、感染组、输卵管积水组及其他原因组。结果全胚冷冻后首次FET组的胚胎着床率、临床妊娠率、及流产率分别为34.6%、40.6%、6.1%,与新鲜胚胎移植组的31.8%、35.7%、4.9%相比,胚胎着床率及临床妊娠率有增加趋势,但无统计学差异(P均>0.05)。FET各组间胚胎着床率、临床妊娠率及流产率在数值上存在不小差异,但无统计学显著性。结论不同因素所致FET的临床妊娠结局存在一定差异。在不适宜或不能行新鲜胚胎移植时,全胚冷冻后行FET是很好的选择,但是否需行全胚冷冻需结合患者各方面因素综合考虑。
Objective： To investigate if the clinical outcomes of frozen-thawed embryo transfer （FET）is better than those of fresh embryo transfer. Methods： A total of 165 patients with frozen-thawed embryo transfer and 1,951 patients with fresh embryo transfer from January 2010 to December 2011 were analyzed retrospectively. According to the reasons of cryopreservation of embryo, the FET patients were divided into six groups： ovary hyperstimulation syndrome group, progesterone elevation group, abnormal endometrium group, potential infection group, hydrosalpinx group and other reason group. Results： The implantation rate,clinical pregnancy rate and abortion rate in FET group were 34.6%, 40.6% and 6.1%, respectively, while they were 31.8%, 35.7% and 4.9%, respectively in fresh embryo transfer group. The implantation rate and the clinical pregnancy rate in the FET cycles showed a slight increase, but with no statistical difference found. The clinical outcomes in different FET groups were variant. Conclusions： The outcomes were diverse among different FET groups with the varying etiology. FET is a good choice when fresh embryo transfer is either impossible or inconvenient. But the indications of FET should be carefully considered for the individual patients.
出处
《生殖医学杂志》
CAS
2013年第7期500-504,共5页
Journal of Reproductive Medicine
关键词
新鲜胚胎移植
冻融胚胎移植
子宫内膜容受性
着床率
Fresh embryo transfer
Frozen-thawed embryo transfer
Endometrium receptivity
Implantation rate
