摘要
目的观察前列地尔治疗稳定型心绞痛的临床疗效,研究前列地尔对心绞痛病人hs-CRP、Hcy水平表达的影响。方法将50例稳定型心绞痛患者根据治疗方式不同分为治疗组及对照组,治疗组在常规治疗的基础上增加前列地尔,对比两组患者疗效及hs-CRP、Hcy表达改变情况。结果治疗组及对照组心绞痛发作次数均减少,治疗组优于对照组(P<0.05),治疗组及对照组心绞痛发作时间减少,治疗组优于对照组(P<0.01),治疗组及对照组临床症状好转,两组心电图改变方面,治疗组优于对照组(P<0.05)。两组患者治疗后hs-CRP、Hcy表达均低于治疗前,P<0.05。治疗组治疗后hs-CRP、Hcy表达显著低于对照组,结果对比差异有统计学意义。结论前列地尔注射液不仅能够有效地控制稳定型心绞痛的症状,改善心肌缺血,还可以显著降低血清超敏C反应蛋白以及同型半胱氨酸水平。
Objective To observe alprostadil clinical efficacy for the treatment of stable angina,and explore expression of hsCRP and Hcy levels in patients with angina pectoris.Methods 50 patients with stable angina pectoris were divided into a treatment group and the control group,the treatment group on the basis of conventional treatment increased alprostadil,efficacy of the two groups of patients and hs-CRP,Hcy expression changes were recorded and compared.Results In the treatment group and the control group,the number of angina attacks were reduced,the treatment group was less than the control group（P〈0.05） decrease of duration of angina pectoris in both the treatment group and the control group,the treatment group was less than the control group（P〈0.01）,the clinical symptoms were improved in both groups,the treatment group was superior to the control group in ECG changes（P〈0.05）.After treatment,hs-CRP and Hcy expression were lower than before treatment,with P〈0.05.In the treatment group,hs-CRP and Hcy were significantly lower than those of the control group after treatment,the difference was statistically significant.Conclusion Alprostadil injection was not only able to effectively control the symptoms of stable angina and improve myocardial ischemia,can significantly reduce serum high sensitivity C-reactive protein,and homocysteine levels.
出处
《中华全科医学》
2013年第8期1191-1193,F0003,共4页
Chinese Journal of General Practice
