摘要
G蛋白耦联雌激素受体-1(G protein-coupled estrogen receptor 1,GPER-1)是一种新型的雌激素受体,能够介导雌激素的快速非基因组效应。GPER-1与雌激素具有高亲和力,能与天然雌激素和人工合成雌激素结合,快速激活细胞内第二信使或级联信号通路,间接调节转录活动,从而介导雌激素的生物学效应。GPER-1的亚细胞定位存在争议,因其亚细胞定位可能取决于不同的细胞类型。另外,性别、年龄等内在因素以及细胞外刺激、损伤等外在因素也影响GPER-1在质膜的相对丰度。近年来研究表明GPER-1的表达与女性生殖系统肿瘤的发生、发展密切相关,在卵巢癌组织中高表达,参与卵巢癌的发生发展,并可能作为评价卵巢癌患者预后的指标,有望成为卵巢癌重要的治疗靶点。
G protein-coupled estrogen receptor 1（GPER-1） is a novel estrogen receptor,which has been found to mediate the non-genomic effects of estrogen.GPER-1 has a high affinity to natural and synthetic estrogens.It is capable of activating multiple second messengers and rapid signaling pathways,and indirectly regulates transcriptional activities of estrogens.A growing body of evidence has demonstrated that GPER-1 is involved in the tumorigenesis and progression of female reproductive malignancies.GPER-1 is overexpressed in ovarian carcinomas,and predicts the poor outcome of the disease.GPER-1 might serve as a therapeutic target in the treatment of ovarian carcinomas.In the present review,the structure,location and signaling transduction of GPER-1,and its biological functions in ovarian carcinomas were discussed,and its prospect as a new therapeutic target of ovarian carcinomas was also previewed.
出处
《生殖与避孕》
CAS
CSCD
2013年第7期469-472,490,共5页
Reproduction and Contraception
基金
黑龙江省自然科学基金(D201008)
黑龙江省博士后启动基金(LRB04-248)资助
