摘要
线粒体不仅是真核细胞的能量工厂,更是细胞信号转导的调控中心。转换线粒体的功能定位,探索线粒体能量代谢与信号转导之间的偶联机制,将有助于揭示运动与生理适应的链接通路。许多慢性疾病的病理基础可归因于线粒体与真核细胞之间共生关系异常,即以能量换营养的交易出现阻滞,运动有助于整合或恢复这种共生关系。因为运动不仅促进线粒体生物发生(正向适应),也诱导细胞自噬(含线粒体自噬),未来以"自噬"为标志的"逆向适应"研究将更全面地揭示线粒体质量控制的机理,这将进一步丰富运动适应的细胞信号调控理论以及线粒体相关疾病的病理机制。
Mitochondria is not only a eukaryotic cell energy plant,but also the regulation center of cell signal transduction.It is important to convert the traditional mitochondrial function and explore the crosstalk of mitochondrial energy metabolism and signal transduction for revealing the theory of adaption of physical activity.It is the abnormal symbiotic relationship between mitochondria and eukaryotic cells that may inducepathologyof many chronic diseases.That is,the trade of energy for food is retarded.The effect of exercise on mitochondrial quality control involves not onlymitochondrialbiogenesis and dynamics（forward adaptation）,but alsothe induction of autophagy（mitophagy）.In the near future,autophagy,regarded as a＂reverse adaptation＂,may further disclose the underlying mechanisms of Mitochondrial Quality Control,the future resultswill enrich the relationship between exercise adaption and signal regulation,and provide more understandingsfor mitochondria-related diseases.
出处
《体育科学》
CSSCI
北大核心
2013年第7期65-69,共5页
China Sport Science
基金
国家自然科学基金资助项目(31171142)
关键词
线粒体
信号转导
自噬
生物发生
运动适应
mitochondria
signal transduction
autophagy
biogenesis
exercise adaptation
