摘要
目的:观察独一味胶囊联合镇痛活络酊治疗外伤后疼痛、肿胀的疗效和安全性。方法:将80例外伤患者随机均分为治疗组和对照组。治疗组患者口服独一味胶囊,每次3粒,每日3次,并配合外用镇痛活络酊涂抹患处,每日3次;对照组患者仅以镇痛活络酊涂抹患处,每日3次。两组患者均治疗7 d。观察比较两组患者的痊愈率、总有效率、肿胀改善率、疼痛评分、疼痛持续时间和不良反应。结果:治疗后,治疗组患者痊愈率和总有效率为27.5%、92.5%,对照组分别为10.0%、82.5%,两组比较差异有统计学意义(P<0.05);治疗组患者肿胀改善率显著优于对照组(P<0.05);治疗组患者疼痛评分显著低于对照组,疼痛持续时间显著短于对照组(P<0.05)。两组均未见明显的不良反应发生。结论:独一味胶囊联合镇痛活络酊治疗外伤后疼痛、肿胀的疗效较好,可有效缓解疼痛、肿胀,缩短疼痛持续时间,且安全性较好。
OBJECTIVE: To observe the curative effect and safety of Duyiwei capsule Combined with Zhengtong huoluo tinc- ture for post-traumatic swelling and pain. METHODS: 80 patients with post-traumatic swelling and pain were randomly divided in- to treatment group (n=40) and control group (n=40). Treatment group was given Duyiwei capsule 3 pieces, tid, orally and Zhengtong huoluo tincture for external use, lid. Control group only accepted Zhengtong huoluo tincture for external use, tid. A treat- ment course of 2 groups lasted for 7 d. The cure rate, total effective rate, the improvement of swelling rate, pain score, paining du- ration and safety were observed and compared between 2 groups. RESULTS: After treatment, the cure rates and the total effective rates were 27.5%, 92.50% for treatment group and 10.0%, 82.5% for control group, there was statistical significance (P〈0.05). the improvement of swelling rate in treatment group were higher than in control group (P〈0.05). The pain score was lower and paining duration was shortening in treatment group, which were significantly better than those of control group (P〈 0.05). No signif- icant ADR was observed in 2 groups. CONCLUSIONS: Duyiwei capsule Combined with Zhengtong huoluo tincture is effective in the treatment of post-tranmatic pain and swelling, and can relieve pain and swelling and shorten duration of post-traumatic pain with sound safety.
出处
《中国药房》
CAS
CSCD
2013年第28期2644-2645,共2页
China Pharmacy
关键词
独一味胶囊
疼痛
肿胀
疗效
安全性
Duyiwei capsule
Pain
Swelling
Clinical efficacy
Safety