摘要
目的:采用电感耦合等离子体质谱法(ICP-MS法),对小茴香中的金属元素进行分析检测,找出小茴香中与抗肿瘤功效相关的金属元素,初步探究其抗癌机制,为研究小茴香药材及其合理利用奠定基础。方法:通过微波消解和电感耦合等离子体质谱法,采用半定量和定量分析模式,开展小茴香中金属元素定性及定量分析研究,找出与抗癌机制的相关元素,初步探究小茴香抗癌的作用机制。结果:小茴香中Na、Mg、Ca、Fe、Zn、Mn、Ba等金属元素含量较高,初步确定小茴香的抗癌机制与这些金属元素有关。结论:该研究从金属组学角度为开展小茴香抗癌作用机制研究奠定基础。
Objective： Using inductively coupled plasma mass spectrometry to analyze the detection of metallic elements in foeniculi fructus,and to identify the anti-tumor effects of the metal elements in foeniculi fructus,initially to explore the anti-tumor mechanism of foeniculi fructus for its rational use. Methods： By microwave digestion and inductively coupled plasma mass spectrometry,using semi-quantitative and quantitative analysis model,to carry out the metal element in foeniculi fructus qualitative and quantitative analysis of the research to identify the elements associated with anti-tumor mechanisms,preliminary inquiry foeniculi fructus’ antitumor mechanism. Results： The results showed that foeniculi fructus contains a higher content of Na,Mg,Ca,Fe, Zn,Mn,Ba metal elements initially identified through literature research,foeniculi fructus’ anti-tumor mechanism of Na,Mg,Ca, Fe,Zn,Mn and other metals. Conclusion： The group from the metal point of view to lay the foundation for carrying out the mechanism of the anti-tumor effects of foeniculi fructus.
出处
《中国药物评价》
2013年第3期129-131,共3页
Chinese Journal of Drug Evaluation
