摘要
目的了解内皮素-2(ET-2)A985G基因多态性与老年原发性高血压左心室心肌肥厚的关系。方法2010年1月—2012年10月,随机选取就诊于我科、年龄≥60岁原发性高血压病人312例为研究对象,均行彩色多普勒心脏超声检查,根据检查结果分为心肌肥厚组与非心肌肥厚组(对照组),应用基因芯片技术检测ET-2A985G基因多态性,分析ET-2与心肌肥厚相关性。结果心肌肥厚组基因型GG、GA、AA所占的比例分别为59.22%、37.86%、2.91%;心肌肥厚组与对照组间ET-2等位基因分布差异有显著性(χ2=13.57,P<0.01)。Lo-gistic回归分析显示,基因型AG+AA与心肌肥厚有相关性(OR=2.588,95%CI=1.239～5.404)。结论 ET-2的A等位基因可能是高血压致左心室肥厚的危险因素之一。
Objective To understand the association between endothelin-2 （ET-2） A985G polymorphism and left ven- tricular hypertrophy （LVH） in elderiy. Methods During 2010-01 2012-10, 312 seniors of 60 or over who visited our depart ment were enrolled in random for this study. All the patients received color Doppler echocardiography, and were divided into myo- cardial hypertrophy （MH） group and control group based on the results. ET-2 A985G polymorphism was detected by GeneChip, the correlation between ET-2 and MH was then analyzed. Results The ratio of genotypes GG, GA, and AA in MH group ac- counted for 59.22 %, 37.86 % and 2.91%, respectively. The difference of distribution of ET-2 between M H and control groups was significant （x2 = 13.57,P〈0.01）. Logistic regression showed the A allele of ET-2 gene in both MH and control groups was asso- ciated with left ventrieular mass index （0R=2.588,95%CI=1.239--5.404）. Conclusion A allele of ET-2 gene is likely to be one of the risk factors of left ventricular hypertrophy due to hypertension.
出处
《齐鲁医学杂志》
2013年第3期223-225,229,共4页
Medical Journal of Qilu
基金
青岛市科技局资助课题(11-2-4-2-(17)-jch)
关键词
内皮缩血管肽2
高血压
心肌病
肥厚性
多态性
单核苷酸
endothelin-2
hypertension
cardiomyopathy, hypertrophic
polymorphism, single nucleotide
