摘要
目的:探讨B型利钠肽(BNP)在鉴别心源性呼吸困难和肺源性呼吸困难并进行危险度分层及预后评估方面的价值。方法:168例急性呼吸困难患者分为心源性呼吸困难组(A组)112例和肺源性呼吸困难组(B组)56例,A组分左室射血分数(LVEF)≥40%(A_1)和LVEF<40%(A_2)两亚组,B组分右心功能不全(B,)和非右心功能不全(B_2)两亚组,并按28 d内存活与否分为死亡组与存活组,比较各组间的BNP值。结果:A组的BNP值显著高于B组(P<0.01),且A_2组的BNP值显著高于A_1亚组(P<0.01);B_1组BNP水平明显高于B_2组(P<0.05);A组中死亡组BNP值高于其余三组(全部P<0.01)。结论:BNP为辨别心源性呼吸困难和肺源性呼吸困难的可靠指标,并可进行病情严重度分层和预测短期病死率。
Objective：To study the utility of the brain natriuretic peptide （BNP） in the differentiation,risk stratification and evaluation of prognosis of acute dyspnea secondary to cardiac or lung disease. Methods： 168 patients with acute dyspnea were divided into cardiogenic dyspnea group （group A） with 112 cases and pulmonary dyspnea group （group B） with 56 cases. The 112 cases in group A were divided into group At included 54 patients with LVEF≥40% and group A2 included 58 patients with LVEF〈40%. The 56 cases in group B were divided into group B1 included 31 patients with right heart failure and group B2 included 25 patients with not right heart failure. According to the survival within 28 days, the all patients were divided into death group and survival group. BNP were compared among the each group. Results：The value of BNP in group A was significantly higher than that in group B （P〈0.01）, and BNP in A2 subgroup was significantly higher than that in A1 subgroup （P〈0.01） ;In group B, BNP in B1 subgroup was higher than that in B2 subgroup（P〈0.05）. BNP in death subgroup of group A was higher than the other subgroups（all P〈 0.01）. Conclusion： BNP may be a useful adjunct in the differentiation of acute dyspnea of cardiac or pulmonary origin, and would be useful in the availability of risk stratification and prediction of short-term mortality.
出处
《岭南急诊医学杂志》
2013年第3期178-179,共2页
Lingnan Journal of Emergency Medicine
