摘要
目的:分析系统性红斑狼疮合并甲状腺功能减退症50例临床症状和治疗效果。方法:选取2010年6月至2012年6月间于我院接受诊断和治疗的系统性红斑狼疮合并甲状腺功能减退症患者50例作为观察组,同时选取同期入院的单纯系统性红斑狼疮患者50例作为对照组,分析两组临床症状的差异。观察组患者分别给予系统性红斑狼疮合并甲状腺功能减退症联合治疗和甲状腺功能减退症单独治疗,观察比较治疗前后甲状腺功能差异。结果:观察组患者关节病变发病率为64.00%明显高于对照组的22.00%(P<0.05);观察组患者雷诺现象的发病率为36.00%明显高于对照组的6%(P<0.05)。联合治疗患者治疗后促甲状腺素水平明显低于单独治疗(P<0.05),联合治疗患者治疗后游离甲状腺素和游离甲状腺三碘原氨酸水平均明显高于单独治疗(P<0.05)。结论:系统性红斑狼疮合并甲状腺功能减退症患者的关节病变和雷诺现象发病率明显较高,联合治疗后甲状腺功能减退症恢复较佳。
Objective： To analyze the clinical symptom and effect of 50 patients with Systemic Lupus Erythematosus combined with Hypothyroidism.Method： 50 patients with Systemic Lupus Erythematosus combined with Hypothyroidism was selected as observation group while 50 patients with Systemic Lupus Erythematosus were selected as control group.And the clinical symptoms were analyzed.The patients of the observation group were given combination therapy and monotherapy respectively.And the differences between the two methods were compared.Results： The disease incidence of joint disease of the observation group was 64.00% and it was obviously higher than that of the control group（P0.05）.The disease incidence of Raynaud＇s phenomenon of the observation group was 36.00%,and was obviously higher than that of the control group（P0.05）.The level of Thyroid stimulating hormone with combination therapy was obviously lower than that of the monotherapy（P0.05）.The level of free thyroxine and free thyroid iodine original acidwith combination therapy was obviously higher than that of the monotherapy（P0.05）.Conclusion： The disease incidence of joint disease and the Raynaud phenomenon of the patients with Systemic Lupus Erythematosus combined with Hypothyroidism were obviously high,and the combination therapy had a significant effect.
出处
《现代生物医学进展》
CAS
2013年第21期4144-4146,共3页
Progress in Modern Biomedicine
