摘要
目的观察右美托咪啶对ICU慢性阻塞性肺疾病患者撤机后镇静作用。方法成功撤机>12 h的慢性阻塞性肺疾病患者48例,给予右美托咪啶负荷剂量1.0μg.kg-1,滴定维持剂量0.2～0.7μg.kg-1.h-1,保持患者Ramsay镇静深度评分3～4分,给药0、30 min、1、2 h监测INBP、HR、SpO2、PETCO2。结果与0 min比较,30 min、1、2 h SBP明显下降(P<0.05),HR明显下降(P<0.05),完成实验的患者在任何时间点均SBP>90 mmHg,HR>60 mmHg,无微循环灌注不足表现,PETCO2无明显改变(P>0.05)。结论右美托咪啶用于ICU慢性阻塞性肺疾病患者撤机后镇静未产生明显呼吸抑制,血压和心率轻度降低。
Objective To observe the effects of sedation with dexemetomidine in ICU for COPD patients withdrawn from mechanic venti- lation. Methods 48 cases of COPD were enrolled,withdrawn from mechanic ventilation beyond 12 h. Dexemetomidine was administered a bolus of 1.0 μg· kg-1 to all cases with intravenous titration rate at 0.2 -0.7 μg· kg-1 . h- l, targeting Ramsay 3 - 4. INBP, HR, SpO2 , PET CO2 were monitored continuously and recorded at 0 rain,30 min, 1 h,2 h after administration. Results Compared with 0 rain, SBP and HR at 30 min,1 h,2 h statistically decreased（P 〈 0.05） ,without insufficient perfusion in microcirculation. SpO2and PETCO2 did not change significantly（P 〉 O. 05）. Conclusion Dexemetomidine used in ICU for COPD patients withdrawn from mechanic ventila- tion induced only insignificent respiratory depression with mild decrease blood pressure and heart rate.
出处
《安徽医药》
CAS
2013年第6期1022-1023,共2页
Anhui Medical and Pharmaceutical Journal
