摘要
目的研究山沉香Syringa pinnatifolia干燥茎的化学成分。方法采用硅胶、ODS、Sephadex LH-20及RP-HPLC等色谱技术对山沉香干燥茎的化学成分进行分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果从山沉香干燥茎95%乙醇提取物的醋酸乙酯部位分离得到11个化合物,分别鉴定为开环异落叶松脂醇(1)、(8R,8′R,9R)-3,3′,9-三甲氧基-4,4′-二羟基-9,9′-环氧木脂素(2)、(8R,8′R,9S)-3,3′,9-三甲氧基-4,4′-二羟基-9,9′-环氧木脂素(3)、左旋松脂醇(4)、(8R,8′R,9′S)-3,3′,9′-三甲氧基-4,4′-二羟基-9,9′-环氧木脂素(5)、(8R,8′R,9′R)-3,3′,9′-三甲氧基-4,4′-二羟基-9,9′-环氧木脂素(6)、(9S)-9-O-methylcubebin(7)、邻苯二甲酸二丁酯(8)、菲律宾胡椒素VI(9)、蛇菰宁(10)、落叶松萘酮(11)。结论化合物2～11均为首次从该植物中分离得到。
Objective To investigate the chemical constituents from the stems of Syringa pinnatifolia. Methods The chemical constituents were isolated and identified by chromatography on silica gel, ODS, and Sephadex LH-20 columns, as well as RP-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analyses. Results Eleven compounds were isolated from S. pinnatifolia and their structures were identified as secoisolariciresinol （1）, （8R, 8＇R, 9R）-4, 4＇-dihydroxy-3, 3＇, 9-trimethoxy-9, 9＇-epoxylignan （2）, （SR, 8＇R, 9S）-4, 4＇-dihydroxy-3, 3＇, 9-trimethoxy-9, 9＇-epoxylignan （3）, （-）-pinoresinol （4）, （SR, 8＇R, 9＇S）-4, 4＇- dihydroxy-3, 3＇, 9＇-trimethoxy-9, 9＇-epoxylignan （5）, （8R, 8＇R, 9＇R）-4, 4＇-dihydroxy-3, 3＇, 9＇-trimethoxy-9, 9＇-epoxylignan （6）, （9S）-9- O-methylcubebin （7）, dibutylphthalate （8）, piperphilippinin Ⅵ （9）, balanophonin （10）, and larixnaphthaone （11）. Conclusion Compounds 2-11 are isolated from the plant for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2013年第13期1721-1725,共5页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81072535)
中央高校基本科研业务费专项资金(21612417)
