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普萘洛尔在家族性肝癌TACE围术期应用的安全性和近期疗效

Recent efficacy and safety of propranolol taken orally the primary liver cancer (PLC) patients during the perioperative period in transcatheter arterial chemoembolization
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摘要 目的观察普萘洛尔在家族性肝癌肝动脉栓塞化疗(transcatheter arterial chemoembolization,TACE)围术期应用的安全性和近期疗效。方法 TACE术前3天开始口服普萘洛尔,自10mg/次起,逐日增加5mg至20mg/次,3次/天,术后继续口服普萘洛尔共4w。结果 9例患者共接受TACE治疗21次,平均2.3次(1~4次)。9名患者均可评价疗效,其中CR2例,PR4例,SD1,PD2例,RR67.7%(6/9)。6个月生存率88.9%(8/9),12个月生存率66.7(6/9),18个月生存率33.3%(3/9)。介入并发症主要有呕吐1例,腹痛6例,发热4例。毒副反应中性粒细胞Ⅲ抑制1例,无Ⅳ度抑制。结论普萘洛尔在家族性肝癌患者TACE围术期应用的近期有效率67.7%,未观察到严重和特别的并发症及毒副反应。 Objective: To observe recent efficacy and safety of propranolol taken orally the familial genetics patients with primary liver cancer(PLC) during the perioperative period in transcatheter arterial chemoembolization(TACE).Methods: Totally 9 familial genetics patients with PLC had taken orally propranolol the third day before TACE for four weeks,propranolol 20mg one time and three times one day.Results: The response rate was 67.7%(6 /9) by Response Evaluation Criteria in Solid Tumors(RECIST).CR,PR,SD,PR were respectively 2,4,1,2 cases.The 6-month,12-month and 18-month survival rates were respectively 88.9%(8 /9),66.7(6 /9),33.3%(3 /9).Complication were 1 case of vomiting,6 cases of abdominal pain,4 cases of fever.Adverse reactions included 1 case of Ⅲ degree neutropenia inhibition.Conclusion: The familial genetics patients with PLC had taken orally propranolol during the perioperative period in TACE that was efficacy and safety.
出处 《中国优生与遗传杂志》 2013年第7期134-135,63,共3页 Chinese Journal of Birth Health & Heredity
关键词 肝癌 家族性 肝动脉栓塞化疗术 普萘洛尔 近期疗效 安全性 Primary liver cancer Familial genetics Transcatheter arterial chemoembolization Propranolol Recent efficacy Safety
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  • 1L6aut6 -Labr:ze C, de la Roque ED, Hubiche T, et al. Propranolol for severe hemangiomas of infancy [ J ]. N Engl J Med, 2008,358 (24) : 2649 -2651. 被引量:1
  • 2Westfall TC, Wesffall DP. Adrenergic agonists and antagonists [ M ]// Brunton LL, Lazo JS,Parker KL. Goodman and Gilman' s The Phar- macological Basis of Therapeutics. 11 th ed. NewYork : McGraw - Hill ,2006.271 - 295. 被引量:1
  • 3Borgstrom P, Hillan K, Srlramarao P, et al. Complete inhibition of anlgiogenesis and growth of microtumors by anti vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic ther- apy from intravital videomicroscopy [ J ]. Cancer Res, 1996, 56 : 4032 - 4091. 被引量:1
  • 4Iacearino G, Ciccarelli M, Sorriento D, et al. tschemie neoangiogene- sis enhanced by beta2 adrenergic receptor overexpression - a novel role for the endothelial adrenergic system [ J ]. Circ Res, 2005,97 (11): 1182 -1189. 被引量:1
  • 5Parenti A, Morbidelli L, Cui XL, et al. Nitric oxide is an up-stream signal of vascular endothelial growth factor - induced extracellular sig- nal regulated kinase 1/2 activation in postcapillary endothelium[ J].J Biol Chem, 1998,273 (7) : 4220 - 4226. 被引量:1
  • 6Fredriksson JM, Lindquist JM, Bronnikov E, et al. Norepinephrine induces vascular endothelial growth factor gene expressionin brown adipocytes through a beta - adrenoceptor/eAMP/proteinkinase A pathway involving src but independently of Erkl/2 [ J]. J Biol Chem, 2000,275(18): 13802 -13811. 被引量:1
  • 7Zhang D, Ma Q, Shen S, et al. Inhibition of pancreatic cancerceU proliferation by propranolol occurs through apoptosis induction [ J ]. Pancreas ,2009,38( 1 ) : 94 - 100. 被引量:1
  • 8A1 - Wadei HA, A1 - Wadei MH, Schuller HM. Prevention of pan- creatic cancer by the beta - blocker propranolol [ J ]. Antieaneer Drugs,2009,20 (6) : 477 - 482. 被引量:1
  • 9刘合代,丁罡,张明,赵其德,倪裕丰.原发性肝细胞肝癌的家族聚集性研究——附8个家系34例患者的临床分析和家系调查[J].中国优生与遗传杂志,2007,15(1):110-111. 被引量:8

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