摘要
目的比较体外受精-胚胎移植(IVF-ET)与单精子卵胞浆内注射(ICSI)受孕双胎妊娠围生期并发症及结局。方法回顾性分析我院2004年2月～2011年5月437例IVF-ET、ICSI受孕双胎的并发症(如胎膜早破、胎盘早剥、妊娠期高血压疾病、妊娠期肝内胆汁淤积症)及妊娠结局(流产发生率)。结果 IVF-ET受孕双胎组胎膜早破及胎盘早剥发生率高于ICSI受孕双胎组(χ2=5.93,6.01;P<0.05);IVF-ET受孕双胎组与ICSI受孕双胎组妊娠期高血压疾病、妊娠期肝内胆汁淤积症发生率无统计学差异(χ2=2.68,1.37;P>0.05);IVF-ET受孕双胎组较ICSI受孕双胎组流产率高,差异有统计学差异(χ2=5.09;P<0.05)。结论 IVF-ET较ICSI受孕双胎妊娠风险较高,IVF-ET与ICSI本身可能不是导致妊娠期高血压疾病、妊娠期肝内胆汁淤积症的因素。
Objective：To investigate the outcomes and complications of twin pregnancy by in vitro fertilization-embryotransfer（IVF-ET） and intracytoplasmic sperm injection（ICSI）.Methods：A retrospective study was carried out to measure premature rupture of membrane,placental abruption,pregnancy-induced hypertension,intrahepatic cholestasis of pregnancy and abortion,437 twin pregnant women who achieved pregnancy by IVF—ET or ICSI in our hospital from February,2004 to May,2011 had participated the study.Results：Incidences of premature rupture of membrane and placental abruption in IVF-ET group were significant higher than in ICSI group（χ2=5.93,6.01;P0.05）;Ratios of pregnancy-induced hypertension and intrahepatic cholestasis of pregnancy between IVF-ET and ICSI group were no significant differences（χ2=2.68,1.37;P0.05）;Ratio of abortion in IVF-ET group was significant higher than that in ICSI group（χ2=5.09;P0.05）.Conclusion：The risk of twin pregnancy by IVF-ET is higher than by ICSI,IVF-ET and ICSI maybe are not the main cause of pregnancy-induced hypertension and intrahepatic cholestasis of pregnancy.
出处
《中国优生与遗传杂志》
2013年第6期99-100,140,共3页
Chinese Journal of Birth Health & Heredity
关键词
体外受精-胚胎移植
单精子卵胞浆内注射
双胎妊娠
In vitro fertilization-embryotransfer
intracytoplasmic sperm injection
twin pregnancy
