摘要
目的:探讨舒肝颗粒治疗更年期焦虑症的临床疗效及生物学机制。方法:采用自身病例对照研究,比较177例更年期焦虑症患者在舒肝颗粒治疗前和治疗6～8周后实验室指标催乳素(PRL)、雌二醇(E2)、一氧化氮(NO)、一氧化氮合酶(NOS)及脑源性神经营养因子(BDNF)的变化及汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分变化。结果:给予舒肝颗粒每次3g,一天2次治疗6～8周后,患者的PRL、NO水平均明显降低,BDNF较治疗前明显升高,治疗后HAMA评分明显降低。治疗6～8周后HAMA降低的水平与PRL降低水平呈正相关。结论:舒肝颗粒对更年期焦虑症患者有一定的临床疗效,其作用机制可能是一方面通过降低血清PRL水平直接缓解焦虑,另一方面可能是通过NO系统,调节神经营养通路而发挥作用。
Objective：To observe the clinical effect and study the neural mechanism of Shugan Granule to treat climacteric anxiety.Methods： Using self-control method,the levels of PRL,E2,NO,NOS,BDNF and the scores of HAMA were measured at the baseline and the end of 6 ～ 8 weeks in 177 climacteric anxiety patients treated with Shugan Granule.Result： After 6 ～ 8 weeks treatment with Shugan Granule 3 grams each time,2 times a day,the levels of PRL,NO both decreased significantly,the BDNF levels increased significantly.After Shugan Granule treatment,the scores of HAMA decreased significantly.The scores of HAMA had positive correlation with the levels of PRL.Conclusions： Shugan Granule have some effect to treat climacteric anxiety,the mechanism may be via reduce serum PRL levels to remit anxiety directly,the another way is via the NO system,adjust the neurotrophic path to play a role.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第3期183-185,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
河南省科技厅科技攻关课题(102102310379)
