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溶栓并腔内介入治疗2型糖尿病合并下肢动脉血栓形成的临床分析 被引量:8

Clinical analysis of catheter directed thrombolysis combined with endovascular intervention for lower extremity artery thrombosis in type 2 diabetes patients
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摘要 目的回顾性分析2型糖尿病合并下肢动脉血栓形成患者的临床特点与溶栓并腔内治疗的效果。方法选取2008年1月至2012年12月在解放军第三○六医院采用腔内介入治疗的糖尿病合并急性下肢动脉血栓形成患者46例为研究对象,其中男8例,女38例,平均年龄(68±16)岁,急性下肢缺血病程平均(7±4)d,平均糖尿病病程(8±6)年。根据下肢动脉血栓部位与腹股沟韧带关系,将患者分为中央型(8例)、周围型(22例)及混合型(16例)共3组,分析患者相关临床资料,比较组间导管溶栓治疗的差异,并观察治疗前后踝肱指数(ABI)的变化。多组问比较采用单因素方差分析,两两比较采用Student.Newman—Keuls检验。结果周围型血栓患者导管溶栓尿激酶用量明显小于中央型和混合型患者[分别为(280±40)、(350±60)、(360±40)万U,F=184.47,P〈0.05],周围型血栓患者溶栓持续时间明显小于中央型和混合型患者[分别为(52±12)、(76±20)、(72±14)h,F=1203.39,P〈0.05];而中央型与混合型患者之间上述指标均无明显差异(均P〉0.05)。所有患者溶栓后的残余狭窄均予以腔内介入治疗。治疗完成后踝肱指数(ABI)较术前明显升高[分别为(0.31±0.15)、(0.95±0.31),t=15.312,P〈0.05]。结论对于2型糖尿病合并急性下肢动脉血栓形成患者,血栓范围越广,导管溶栓药量越大,溶栓周期越长;导管溶栓结合腔内治疗的疗效满意。 Objective To investigate the clinical features of the lower extremity artery thrombosis in the type 2 diabetes patients and to evaluate the effect of the catheter directed thrombolysis combined with endovascular intervention. Method A total of 46 type 2 diabetes patients with acute lower extremity artery thrombosis who were performed the catheter directed thrombolysis and the endovascular intervention in the PLA 306th Hospital during the period from January, 2008 to December, 2012 were enrolled in the study. The subjects consisted of 8 males and 38 females aged (68 ± 16) years old with the diabetes duration of (8 ±6) years and the acute limb ischemia duration of (7 ± 4 ) days. The subjects were divided into three groups according to the location of the lower extremity artery thrombosis relative to the inguinal ligament. , which were the central group (8 cases), the peripheral group (22 cases) and the mixed group (16 cases). The treatment process of the catheter directed thrombolysis was compared among the groups and the anke brachial index (ABI) was monitored before and after the treatment. Single factor variance analysis was used for multi-group comparison, and Student-Newman-Keuls test was used for comparison between two groups. Results The needed dosage of urokinase was less in the peripheral group than those in the central and mixed groups ( (280 ± 40), (350 ± 60), (360 ± 40) x 104 U, respectively, F = 184.47, P 〈 0.05 ). The required time for thrombolysis treatment was also less in the peripheral group than in the central and mixed groups ( (52 ± 12), (76 ± 20), ( 72 ± 14 ) h, respectively, F = 1203.39, P 〈 0.05 ). Between the central group and the mixed group, no statistical difference was observed in the needed urokinase dosage or the required thrombolysis time ( P 〉 0.05 ). After the catheter directed thrombolysis, all residual stenoses were treated with the endovascular intervention. The ABI was significantly increased by the
出处 《中华糖尿病杂志》 CAS CSCD 2013年第6期328-331,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 糖尿病 2型 下肢动脉硬化闭塞症 血栓 重症肢体缺血 血管腔内介入治疗 Diabetes mellitus,type 2 Lower extremity arteriosclerosis obliterans Thrombosis Critical limb ischemia Endovascular intervention therapy
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  • 1范隆华,符伟国,叶建荣,郭大乔.下肢动脉硬化部位与血糖水平关系[J].中国综合临床,2004,20(11):1031-1032. 被引量:2
  • 2罗盈怡,李觉余,金明,布艾加尔.哈斯木,胡大一.吸烟对下肢动脉疾病影响的研究[J].中华医学杂志,2005,85(43):3071-3073. 被引量:19
  • 3许樟荣,顾洪斌.糖尿病足--下肢动脉疾病与肢体保留[M].天津:天津科技翻译出版公司,2011:2-4. 被引量:1
  • 4Klevsgard R, R sber$ BO, Thomsen MB, et al. A l-year folk w-up quality of life study after hemodynamically successful or unsuccessful surgical revascular- ization of lower limb ischemia[ J ]. J Vasc Surg,2001,33 :114-122. 被引量:1
  • 5Molly KJ, Nasim A, London N,I, et al. Percutaneous transluminal angioplasty in the treatment of critical limb isehemia[ J]. J Endovase Ther,2003,10:298- 303. 被引量:1
  • 6Ruef J, Hofmann M, Haase J. Endovascular intervention in iliac and infraingui- hal occlusive artery disease[J]. J Interv Cardiol,2004,17:427-435. 被引量:1
  • 7Johnston KW. Femoral and popliteal arteries : reanalysis of results of balloon an- gioplasty[ J]. Radiology, 1992,183:767-771. 被引量:1
  • 8Dorros G, Jaff MR, Dotros AM, et al. Tibioperoneal (outflow lesian) angio- plasty can be used as primary treatment in 235 patients with critical limb ische- mia: five-year follow-up[J]. Circulation,2001,104:2057-2062. 被引量:1
  • 9Clark TW, Groffsky JL, Soulen MC. Predictors of long-term patency after femo- ropopliteal angioplasty: results from STAR registry J . J Vasc lnterv Radiol, 2001,12:923-933. 被引量:1
  • 10Schillinger M, Mlekusch W, Haumer M, et al. Angioplasty and elective stent- ing, of de novo versus recurrent femoropopliteal lesions: 1 -year follow-up J . J Endovasc Ther, 2003,10:288-297. 被引量:1

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