摘要
目的利用基于体素的形态测量学（VBM）方法，探测不同核型特纳综合征（TS）患儿脑灰质体积异常的差异。方法19例染色体核型为45XO的单体型Ts患儿和21例杂合核型的Ts患儿以及20名正常儿童（对照组）进行了韦氏智力测量和3．0TMR扫描。单体型Ts患儿组、杂合型Ts患儿组和对照组的全脑高分辨率T1WI图像采用统计参数图（SPM）8软件包进行VBM分析，以全脑灰质总体积为协变量，比较3组之间全脑灰质体积的差别，采用功能神经图像分析软件AFNI软件包中的蒙特卡洛模拟方法（AlphaSim方法）进行簇水平上的多重比较校正。结果单体型TS组患儿韦氏总智商值为（89±16）分，杂合型Ts组为（91±13）分，而对照组韦氏总智商值为（109±15）分，3组智商差异具有统计学意义（F=10．75，P〈0．05）。与对照组比较，单体型Ts组及杂合型TS组均表现双侧楔叶、中央后回、扣带回灰质体积减小，差异有统计学意义（单体型Ts组统计区体素数目分别4117、1392、1085，t值分别为5．75、5．33、5．02；杂合型Ts组统计区体素数目为4501、2437、591，t值分别为5．40、5．11、4．95，P值均〈0．01，FWE校正）；两组TS患儿均在眶额回、海马旁回、小脑、岛叶，右侧颞极、纹状体，中脑背侧灰质体积增加，差异有统计学意义（单体型TS组统计区体素数目分别为1444、1188、791、725、695、431、386，t值分别为5．01、5．96、5．67、5．23、4．85、4．43、4．94；杂合型TS组统计区体素数目分别为6988、2709、2510、2380、1987、1709、1185，t值分别为6．50、7．06、7．26、5．27、5．71、6．02、4．56，P值均〈0．01，FWE校正）。单体型Ts组与杂合型Ts组比较，杂合型Ts组在左侧海马、纹状体较单体型Ts组灰质体积增加（体素数目分别为1014、496，中心坐标t值分别为4．75和4．53，P值均〈0．01，FWE校正），在右侧缘上回
Objective To detect the difference of cerebral gray matter change in children with different karyotype Turner Syndrome （TS） by using voxel-based morphometry （VBM）. Methods Nineteen children with 45XO karyotype TS,21 children with heterozygous TS and 20 age-matched control girls were recruited in this study. Wechsler intelligence scale for children was used to obtain their intelligence quotients （IQ）. High-resolution magnetic MR imaging was performed in TS children and control girls to collect the whole brain structural data. The data was analyzed by VBM based on SPM8 to compare the volume of gray matter among the monosomy TS children, heterozygous TS children and normal controls by using covariance analysis. Alphasim method in the software of analysis of functional neuroimages （AFNI） was used for clusterlevel multiple comparison. Results The IQ was 89 ± 16 for the monosomy TS children,and it was 91 ± 13 for heterozygous TS children and 109 ± 15 for the controls. Statistical analysis revealed significant difference of IQ among them （ F = 10. 75, P 〈 0. 05 ）. Compared with normal controls, both monosomy TS children and heterozygous TS children showed significantly decreased volume （voxel numbers in clusters were 4117,1392, 1085 ,t =5.75,5.33 and 5.02 for monosomy TS; voxel numbers in clusters were 4501,2437,591 ,t =5.40, 5.11 and 4. 95 for heterozygous TS respectively, P 〈 0.01, FWE-corrected） in the gray matter of bilateral precuneus lobule, postcentral gyrus, and cingulum cortex. However, the volume of the orbitofrontal lobe, parahippocampal gyrus, cerebellum, temporal pole, corpus striatum and posterior midbrain were increased in the monosomy and heterozygous TS children compared to the controls （voxel numbers in clusters were 1444, 1188,791,725,695,431,386, t = 5.01,5.96,5.67,5.23,4. 85,4.43,4. 94 for monosomy TS ; voxel numbers in clusters were 6988,2709,2510,2380,1987,1709,1185, t = 6. 50,7.06,7.26,5.27,5.71,6. 02, 4. 56 for heterozygous TS,P 〈 0. 01, FWE-corrected）. Compa
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2013年第7期607-612,共6页
Chinese Journal of Radiology
基金
国家自然科学基金资助项目（81271649）
关键词
特纳综合征
磁共振成像
儿童
Turner syndrome
Magnetic resonance imaging
Child
