摘要
目的观察灯盏花素对心内直视手术患儿是否具有肾功能保护作用。方法择期行房、室间隔缺损修补术患儿30例,美国麻醉医师协会(ASA)分级Ⅱ～Ⅲ级,年龄12～45个月,随机分成对照组(C组,0.9%氯化钠注射液)、灯盏花素组(B组,0.75 mg/kg),每组15例。麻醉诱导后微泵静脉输注15 mL 0.9%氯化钠注射液或灯盏花素注射液,30 min内输注完毕。分别于切皮前(T0),主动脉阻断开放后30 min(T1)、1 h(T2)、术后6 h(T3)及24 h(T4)测定血前降钙素(PCT)、血肌酐(Cr)及同时间点新鲜尿液的尿N-乙酰-β-D氨基酸葡萄糖苷酶(NAG)浓度。结果与T0点相比,两组患儿PCT及NAG其他时间点都显著升高(P<0.01),而Cr浓度改变差异无统计学意义(P>0.05)。与C组相比,B组PCT及NAG在T1～T4时间点较低(P<0.01),但Cr浓度改变差异无统计学意义(P>0.05)。结论体外循环前静脉输注0.75 mg/kg灯盏花素,有助于减轻体外循环心内直视手术所致的肾功能损伤。
Objective To observe the protective effects of breviscapine on the kidney function in children undergoing open heart surgery under cardiac pulmonary bypass.Methods Thirty children（ASA II or III,aged 12-45 months） were randomly assigned to the control group（C,0.9%chloride sodium） and the breviscapine group（B,breviscapine 0.75 mg/kg）,15 cases each group.15 mL of 0.9%chloride sodium or Breviscapine Injection was administered with pump within 30 min after the induction.The concentrations of procalcitonin（PCT） and N-acetyl-βD-glu-cosaminidase（NAG） and creatinine（Cr） were measured at the timepoints of before skin incision（T0）,at 30 min（T1） and 1 h（T2） after aortic unclamping and at postoperative 6 h（T3） and 24 h（T4）.Results Compared with the T0,the concentrations of PCT and NAG at T1-T4 in the two groups were increased（P 〈0.01）,but the Cr concentrations at T1-T4 had no difference between the two groups（P 〉0.05）.Compared with the group C,the concentrations of PCT and NAG at T1-T4 in the group B were lower（P 〈0.01）,but the difference in the change of the Cr concentrations at T1-T4 had no differences（P 〉0.05）.Conclusion The intravenous infusion of breviscapine 0.75 mg/kg before the starting of CPB is conducive to relieve the kidney function injury caused by open heart surgery under CBD.
出处
《中国药业》
CAS
2013年第13期17-19,共3页
China Pharmaceuticals
关键词
心内直视手术
体外循环
肾功能损伤
灯盏花素
儿童
open heart surgery
cardiopulmonary bypass
kidney function injury
breviscapine
children
