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视黄醇结合蛋白4和心血管疾病危险因素 被引量：3

Retinol binding protein 4 and cardiovascular disease risk factors
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摘要 脂肪组织不仅是一个储备能量、提供能量的器官，更是重要的内分泌器官。2005年美国哈佛大学医学中心鉴定出一种新的参与胰岛素抵抗的脂肪细胞因子——视黄醇结合蛋白4（RetinolBindingprotein，RBP4）。随后多项研究表明其可诱导胰岛素抵抗，并且发现血浆RBP4水平在2型糖尿病、肥胖、代谢综合征以及心血管疾病中均有升高。同时国内外一些研究报道了它与脂质代谢、动脉粥样硬化、糖代谢、胰岛素抵抗、高血压、心力衰竭等心血管疾病相关危险因素的相关性。本文综述RBP4的结构、功能、测定及其在心血管疾病中的研究进展。
作者 李非 杨天伦
机构地区 中南大学湘雅医院心内科
出处 《中国心血管病研究》 CAS 2013年第7期552-556,共5页 Chinese Journal of Cardiovascular Research
关键词 视黄醇结合蛋白4 脂质代谢 胰岛素抵抗 动脉粥样硬化 炎症细胞因子 Retinol Binding protein 4 Lipometabolism Insulin resistance Atherosclerosis Inflammatory cytokines
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献43

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二级参考文献61

共引文献39

同被引文献51

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中国心血管病研究
2013年 第7期

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