摘要
目的探讨肝门部胆管癌的临床分型、治疗方案和疗效。方法选择2008年1月至2011年2月诊治的135例肝门部胆管癌患者作为研究对象,回顾性分析患者的临床分型、治疗情况及预后。结果 135例肝门部胆管癌患者中,Bismuth分型法:Ⅰ型39例,Ⅱ型27例,Ⅲ型25例、Ⅳ型34例、Ⅴ型10例。其中行切除术51例,包括根治性切除术21例、姑息性切除术30例。未切除84例,包括胆-肠吻合术28例、胆道置管引流术36例、金属支架置入术17例、放弃治疗3例。Ⅰ～Ⅱ型的18个月和24个月生存率分别为78.8%和63.6%,Ⅲ～Ⅴ型的18个月,24个月生存率分别为62.3%和44.9%,组间差异有统计学意义(P<0.05)。切除组患者的12个月、18个月和24个月生存率分别为88.2%、80.4%和72.5%,未切除组患者的12个月、18个月和24个月生存率分别为73.8%、63.1%和47.6%,组间差异有统计学意义(P<0.05)。结论肝门部胆管癌的临床分型、治疗方案直接影响患者预后,临床上要根据患者具体病情选择适合的治疗方案,延长患者生存时间。
Objective To analyze the clinical classification,therapeutic regimen and efficacy of 135 patients with hilar cholangiocarcinoma and provide reference data for clinical.Methods From January 2008 to February 2011 in our hospital,135 patients with hilar cholangiocarcinoma were selected as the object of study,the clinical classification,therapeutic regimen and e prognosis of patients were analyzed retrospectively.Results 135 cases of patients with hilar cholangiocarcinoma,Bismuth typing method prompted that 39 cases of type Ⅰ,27 cases of type Ⅱ,25 cases of type Ⅲ,34 cases of type Ⅳ,10 cases of type Ⅴ,51 cases were treated with resection,included 21 cases of radical resection,30 cases of palliative resection,84 cases were treated without resection,included 28 cases of bile-intestinal anastomosis,36 cases of drainage,17 cases of metal stent and 3 cases without treatment,the 18-months,24-months survival rate of type Ⅰ and II were 78.8% and 63.6%,the 18-months,24-months survival rate of type III,IV and V were 62.3% and 44.9%,the differences were statistically significant between two groups（P 0.05）;the 12-months,18-months,24-months survival rate of resection group were 88.2%,80.4% and 72.5%,and the non-resection group were 73.8%,63.1% and 47.6%,the differences were statistically significant between two groups（P 0.05）.Conclusions The clinical classification,therapeutic regimen of hilar cholangiocarcinoma can directly affect the prognosis of patients,clinicians should select appropriate treatment program in accordance with the specific conditions of patients and prolong their survival.
出处
《中国肿瘤临床与康复》
2013年第6期566-568,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肝门部胆管癌
临床分型
治疗方案
疗效
Hilar cholangiocarcinoma
Clinical classification
Therapeutic regimen
Efficacy
