摘要
目的:通过观察胎盘滋养细胞中缺氧诱导因子-Ⅰα(HIF-1α)在妊娠期高血压疾病孕妇与正常孕妇胎盘中的表达差异,探讨其在妊娠期高血压疾病发病中的作用。方法:采用免疫组化法检测112例妊娠期高血压疾病患者(观察组)及110例正常孕妇(对照组)胎盘组织中的HIF-1α蛋白的表达。结果:妊娠期高血压疾病组缺氧诱导因子HIF-1α的表达明显高于正常妊娠组。妊娠高血压疾病组中,病情较重,阳性表达率越高,三组两两比较,均有统计学差异。结论:妊娠期高血压疾病患者胎盘组织HIF-1α明显高于正常孕妇,且随患者病情加重其表达明显升高,说明缺氧诱导因αHIF-1α在妊娠期高血压疾病发病中起重要作用。
Objective： To investigate the expression of hypoxia inducible factor-1 alpha （HIF-1α） in placenta tissue of hypertensive disorder complicating pregnancy patients, and study the functions of HIF-1α in pregnancy induced hypertension（PIH）. Method： The level of HIFla in placenta in 112 patients with hypertensive disorder complicating pregnancy （observation group） and 110 normal pregnant （control group） were detected by immunohistology. Results： HIF - 1α in placenta with PIH was significantly higher than that in control group; HIF- 1α in moderate and severe PIH were significantly higher than that in mild PIH. Conclusion： The results suggest that abnormal expression of HIF - 1α may play an important role in the changes of the pathophysiology of PIH and may be used as an indicator for the severity of PIH.
出处
《陕西医学杂志》
CAS
2013年第7期793-795,共3页
Shaanxi Medical Journal
关键词
高血压
妊娠/免疫学
缺氧诱导因子1
α亚单位/分析
妊娠滋养细胞疾病
胎盘
Hgpertension,Pregnancy -induced/immunology Hypoxia -inducible factor 1 alpha subunit/analysis Gestational trophoblastic disease Placenta
