摘要
维A酸类药物因其抗肿瘤效应用于非黑素皮肤肿瘤的化学预防。异维A酸与阿维A均能有效降低非黑素皮肤肿瘤的发生。根据适应证用维A酸类药物进行化学预防时，推荐从低剂量开始逐渐增加剂量，达到能耐受的最小有效维持剂量，并根据疗效、临床耐受性等调整治疗剂量。维A酸类药物化学预防的可能机制是激活维A酸受体及维A酸x受体并影响其表达，调节转录因子活化因子-1及影响信号通路B—Raf／Mek／Erk、Stat3及核因子-KB等，调节细胞周期、诱导细胞凋亡。
Retinoids have been used for chemoprevention of nonmelanoma skin cancer （NMSC） because of their anti-cancer properties. Both isotretinoin and acitretin can effectively reduce the incidence of NMSC. When administrated for chemoprevention, the dose of retinoids should be low at the beginning, increased step by step to a tolerated minimum maintenance value, and adjusted according to clinical response and tolerance. Retinoids may exert their chemopreventive effects likely by activating retinoic acid receptors and retinoid X receptors and influencing their expressions, regulating the nuclear transcription factor activator protein-1 （AP-1） and inhibiting many signaling pathways including B-Raf/Mek/Erk, Stat3 and nuclear factor- kappa B. Furthermore, retinoids could trigger cell cycle and induce cell apoptosis.
出处
《国际皮肤性病学杂志》
2013年第4期232-234,共3页
International Journal of Dermatology and Venereology
关键词
皮肤肿瘤
维甲酸
药物制剂
化学预防
Skin neoplasms
Tretinoin
Pharmaceutical preparations
Chemoprevention
