摘要
目的:研究麻黄-附子药对主要有效成分在麻黄附子细辛汤及麻黄附子甘草汤中的含量差异,为方剂配伍的科学性提供试验依据。方法:采用HPLC测定汤剂中麻黄-附子药对麻黄的有效成分去甲基伪麻黄碱、去甲基麻黄碱、麻黄碱、伪麻黄碱、甲基麻黄碱及附子的有效成分苯甲酰新乌头原碱、苯甲酰次乌头原碱的含量。结果:药对及2种汤剂中5种麻黄生物碱的含量无显著性差异,附子中的苯甲酰新乌头原碱、苯甲酰次乌头原碱有显著性差异。结论:麻黄-附子药对主要药效成分在不同方剂中含量的差异与其临床应用相关,但具体原因尚不明确。
Objective： Study on the content of main active compounds in the compatibility Ephedra Herba with Radix Aconiti Lateralis in Mahuang Fuzi Xixin decoction and Mahuang Fuzi Ganeao decoction, provide experimental basis for scientific prescripti compatbility. Method： HPLC was adopted to analyzed the content of norpseudoephedrine （NMP）, norephedrine （NME）, ephedrine （E）, pseudoephedrine （PE）, methylephedrine （ME）, Benzoyl mesaconine and Benzoyl hypaeoi-tine which are the major active compounds of compatibility Ephedra Herba with Radix Aconiti Lateralis. Result： The five alkaloid of Ephedra Herba showed little change, but had significant difference in active compounds of Radix Aconiti Lateralis. Conclusion： The content of main active compounds in the compatibility Ephedra Herba with fuzi in two decoction had difference related to its clinical application, but the exact eakse in not clear.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第13期137-140,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81030066)
关键词
麻黄
附子
药对
麻黄附子细辛汤
麻黄附子甘草汤
Ephedra Herba
Radix Aconiti Lateralis
compatibility
Mahuang Fuzi Xixin decoction
Mahuang Fuzi Gancao decoction
