摘要
本文对肺心病人69例和健康对照50例的红细胞(RBC)膜带3蛋白(band 3 protein),RBC内、外血气和电解质进行了研究。结果表明,肺心病Ⅱ型呼吸衰竭病人RBC膜带3蛋白相对含量降低,HCO_3^-/Cl^-交换受限,可能是加重其CO_2潴留和呼吸性酸中毒的原因之一;肺心病Ⅱ型呼吸衰竭病人RBC内相对偏碱是由于RBC内HCO_3^-(〔HCO_3~_〕i)相对升高所致;肺心病低氧血症时,应及时给氧,不仅能改善细胞外酸碱状态,而且可提高细胞内PO_2(PiO_2),增加组织贮氧能力。
The changes of erythrocytic membrane band 3 protein and intraery-throcytic and extrar rythrccytic gases and electrolytes were studied in 69 cases of cor pulmonale and 50 normal subjects.It was found that in the patients of cor pulmonale accompanied with type Ⅱ respiratory failure,the relative low level of erythrocytic membrane band 3 protein and the restriction of HCO-3/Cl-exchange were the factors to aggravate CO2 retention and respiratory acidosis,relative intraerythrocytic alkalosis resulted from the relative increase of intra-erythrocytic HCO-3([HCO-3]),and prompt adminstration of oxygen to cor pulmonale patients with hypoxemia could not only improve extraerythrocytic acid-base imbalance but also increase intraerythcocytic P5O2 and the tissue capacity to store oxygen.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第6期545-550,共6页
Journal of Third Military Medical University
关键词
肺心病
红细胞膜
酸碱失衡
Pulmonary heart disease
respiratory insufficiency
erythrocyte membrance
band 3 protein
acid-base imbalance
