摘要
海马注射精氨酸加压素(AVP)既可延缓大鼠穿梭箱被动回避行为的消退,又可促进这种行为的获得。海马注射6-羟多巴胺(6-OHDA)可阻断AVP的促记忆效应。用高效液相色谱-电化学检测法(HPLC-ECD)观察到,AVP可加速海马内儿茶酚胺的降解。结果提示:(1)AVP可易化大鼠穿梭箱被动回避行为;(2)AVP对动物的长时记忆和短时记忆均有增强作用;(3)AVP对记忆的影响很可能通过加强海马内去甲肾上腺素和/或多巴胺的降解代谢来实现。
Arginine-8-vasopressin (AVP) could promote the acquisition of shuttle-box passive avoidance behavior and delay the extinction of the behavior when injected into the hippocampus of rats.Intrahippocampal injection of 6-hydroxydopamine (6-OHDA) prevented AVP from enhancing memory.The authors had also observed that AVP could accelerate the degradation of cate-cholamine in the hippocampus when the contents of monoamine transmitters and their metabolites were analyzed with high-performance liquid chromatography and electrochemical detection. These facts suggest that vasopressin promotes the shuttle-box passive avoidance behavior in rats,strcnthens long-term memory as well as short-term memory,and exerts its effect on memory through its enhancing the degradation of norepinephrine and/or dopamine in the hippocampus.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第6期551-554,共4页
Journal of Third Military Medical University
关键词
海马
加压素类
记忆
行为
vasopressin
hydroxydopamines
hippocampus
memory
behavior
rat
