摘要
目的探讨Ku70和Ku80在食管鳞癌中的表达及其与同步放化疗敏感性和预后的相关性。方法应用免疫组织化学方法检测Ku70和Ku80在117例食管鳞癌组织中的表达，并分析其表达与临床病理参数、近期疗效和预后的相关性。结果Ku70和Ku80在117例食管鳞癌组织中阳性表达率分别为59．0％（69／117）和50．4％（59／117）。Ku70和Ku80表达均与食管鳞癌的近期疗效相关（P=0．017、0．012），在完全缓解患者中Ku70和Ku80有更低的阳性表达率[49．2％（32／65）、40．0％（26／65）]。但Ku70和Ku80表达与食管鳞癌患者年龄、CT病变长度、淋巴结转移无相关性（P〉0．05）；Ku70表达和Ku80表达之间也无相关性（P=0．114）。Kaplan—Meier分析发现Ku70和Ku80阳性表达的患者具有更差的预后（Ku70：P=0．004；Ku80：P=0．025）。Cox单因素分析也得出同样的结果（Ku70：P=0．005，HR=1．971，95％Ch1．230—3．159；Ku80：P=0．028，HR=1．659，95％CI：1．057—2．605）；但在Cox多因素分析中，仅Ku70表达是影响食管鳞癌患者预后的独立因素（P=0．033）。结论Ku70和Ku80表达上调可降低非手术食管鳞癌患者同步放化疗敏感性，且Ku70表达上调可预测不良预后，提示Ku70和Ku80可作为备选的预测食管鳞癌同步放化疗敏感性的指标。
Objective To investigate the correlation between the expression of Ku70 and Ku80 in esophageal squamous cell carcinoma and chemotherapy sensitivity and prognosis. Methods The expression levels of Ku70 and Ku80 in esophageal squamous cell carcinoma were measured by immunohistochemistry. The relationship between the expression of Ku70 or Ku80 and clinical pathology parameters, recent curative effect of concurrent chemoradiation and prognosis of the patients were analyzed. Results The positive expression rate of Ku70 and Ku80 was 59.0% （69/117 ） and 50.4% （59/117） in esophageal squamous cell carcinoma. The expression of KuT0 and Ku80 was significantly related to recent curative effect of esophageal squamous cell carcinomas （P = 0.017,0.012）. The patients with complete response had lower positive expression rate of Ku70 and Ku80 [ 49.2% （32/65）, 40.0% （26/65）]. But the expression had no relationship with the age, length of lesions in CT, lymph node metastasis of esophageal squamous cell carcinoma （P 〉 0.05）. There was no relationship between the expression of Ku70 and Ku80 neither （P = 0.114）. KaplanMeier analysis found Ku70 and Ku80 had worse prognosis in patients with positive expression （Ku70： P = 0.004 ; Ku80 ： P = 0.025）. In Cox univariate analysis concluded the same result （Ku70： P = 0.005, HR = 1.971, 95% CI： 1.230-3.159; Ku80： P =0.028, HR =1.659, 95% CI： 1.057-2.605）; but in Cox multivariate analysis, only Ku70 expression was the independent factor （P = 0.033）. Conclusions The upregulation of Ku70 and Ku80 is correlated to decreased concurrent chemoradiation sensitivity. In addition, the upregulation of Ku70 is ton＇elated to worse prognosis. Ku70 and Ku80 can be a prediction index for predicting concurrent chemoradiation sensitivity in esophageal squamous cell carcinoma.
出处
《中国医师进修杂志》
2013年第17期1-4,共4页
Chinese Journal of Postgraduates of Medicine
关键词
食管肿瘤
放射疗法
免疫组织化学
Esophageal neoplasms
Radiotherapy
Immunohistochemistry
