摘要
跨胃粘膜电位(GTPD)是反映胃粘膜完整性的较好指标。本文对90例慢性胃炎患者GTPD的变化及相关因素作了观察,并试用于评价复方铋剂和胃痛灵的疗效。结果表明:慢性胃炎状态下,GTPD明显降低,与粘膜病变程度平行,幽门弯曲菌(Cp)感染者下降更甚。治疗显效则GTPD相应地升高,且与药物作用强弱一致。提示:GTPD是定量性地客观评价药物对慢性胃炎疗效的一项较好指标。
Gastric transmucosal potential difference (GTPD) is a sensitive indicator of the integrity of gastric mucosal barrier. The changes of GTPD were investigated in 90 patients with chronic gastritis to evaluate the efficacy of a 6-week-treatment of TDB or weitonlin.GTPD value decreased in chronic gastritis and the rate of decrease was parallel to the severity of mucosal damdge. Campylobacter pylori (Cp) infection brought about a further decrease of GTPD. A significant recovery of GTPD values was observed after a course of TDB therapy especially in those Cp positive cases, which was accompanied with a signifcant decrease of Cp positive rate, an increase of gastric neutral mucus, and a significant reduction of mucosal infiltration of inflammatory cells. Our data suggest that the determination of GTPD is a simple and useful parameter to evaluate the efficacy of certain therapy for gastric mucosa.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第2期101-105,共5页
Journal of Third Military Medical University
关键词
跨胃粘膜电位
胃炎
疗效
检测
慢性
gastric transmucosal potential difference
gastric mucosal barrier
chronic gastritis
therapeutic efficacy evaluation
