摘要
目的探讨右美托咪定在颅内动脉瘤栓塞术后苏醒期的应用效果及安全性。方法将40例颅内动脉瘤栓塞术患者随机分成2组,按照随机原则分为右美托咪定组(20例)和咪达唑仑组(20例)镇静。观察并记录2组患者给药前、给药后、吸痰拔管时、拔管后5 min、拔管后30 min的心率、血压,拔管时间、谵妄例数。结果通过调整药物剂量使2组患者Ramsay评分在2～4分,右美托咪定组拔管所需时间显著短于咪达唑仑组,谵妄发生率低于咪达唑仑组;2组心率、血压、血氧饱和度差异无统计学意义(P>0.05);右美托唑咪定组有2例出现血压下降(血压<70 mmHg)、2例出现心动过缓,咪达仑组有1例出现血压下降,1例出现心动过缓。结论右美托咪定在颅内动脉瘤栓塞术麻醉苏醒期血液动力学稳定、拔管早、术后并发症少,有利于手术效果的早期评估。
Objective To discuss the effect and safety of dexemedetomidine in intracranial aneurysm embolization during anesthesia recovery period. Methods Forty patients admitted to the intensive care unit （ICU） were in need of sedation. They were randomly divided into dexmedetomidine group （20 cases ） and midazolam group （20 cases）.Two groups of patients were compared in terms of mechanical ventilation time, heart rate, blood pressure before and after drug administration, during and after extubation 5 rain, 30rain, and the number of cases of delirium. Results When Ramsay score of 2 to 4 was achieved by dose adjustment for the two groups of patients, the number of cases of delir- ium and the time of mechanical ventilation of dexmedetomidine group were significantly shorter than those of midazo[am group. The heart rate, blood pressure and SpO2 had no significant change in two groups. Two patients had lower blood pressure and 2 sinus bradycardia occurred in dexmedetomidine group. Only 1 heart rate and 1 blood pressure decreased in midazolam group. Conclusion Dexmedetomidine is ideal for the sedation in intracranial aneurysm embolization after anesthesiaanalepsia period, which has hemodynamic stability, early extubation, less postop- erative complications, and thus facilitates the operation effect of the early assessment.
出处
《安徽医学》
2013年第6期704-706,共3页
Anhui Medical Journal
关键词
右美托咪定
颅内动脉瘤
苏醒期
Dexmedetomidine
Intracranial aneurysm embolization
Recovery period
