摘要
目的探讨糖尿病足溃疡感染病原菌分布,并对其临床耐药性进行分析,为其防治提供参考依据。方法选取116例入住医院的糖尿病足发生溃疡并感染的患者,对患者的溃疡物或脓性分泌物进行培养及药敏分析,分析其之间的相关性。结果 116例患者共分离检出144株病原菌,其中革兰阴性菌78株占54.2%,革兰阳性菌46株占31.9%,真菌20株占13.9%,排名前5位病原菌依次为大肠埃希菌、普通变形菌、金黄色葡萄球菌、类肠球菌、肺炎克雷伯菌,分别占15.3%、9.7%、9.7%、6.9%、6.3%;革兰阴性菌对哌拉西林、阿米卡星、头孢拉定、氨苄西林较敏感,敏感率>75.0%;革兰阳性菌对万古霉素、庆大霉素较敏感,敏感率>87.0%,真菌对氟康唑、伏立康唑较敏感,敏感率>80.0%。结论在临床诊治过程中,可根据临床经验于药敏试验结果之前给予患者相应的治疗。
OBJECTIVE To discuss the distribution of the pathogens causing diabetes foot ulcer infections and analyze the clinical drug resistance so as to provide basis for the clinical prevention.METHODS The participants included 116cases of diabetes foot ulcers patients complicated with infections,then the ulcer content or purulent secretions from the patients were cultured,the drug susceptibility testing was performed,and the correlation between the two was analyzed.RESULTS A total of 144strains of pathogens were isolated from 116cases of patients,including 78（54.2%）strains of gram-negative bacteria,46（31.9%）strains of gram-positive bacteria,and 20（13.9%）strains of fungi;the top five species of pathogens isolated were in turn as the Escherichia coli,Proteus,Staphylococcus aureus,Enterococcus,and Klebsiella pneumoniae,accounting for 15.3%,9.7%,9.7%,6.9%,and 6.3%,respectively.The drug susceptibility testing indicated that the drug susceptibility rates of the gram-negative bacteria to piperacillin,amikacin,cephradine,and ampicillin were more than 75.0%,the drug susceptibility rates of the gram-positive bacteria to vancomycin and gentamicin were more than 87.0%,and the drug susceptibility rates of the fungi to fluconazole and voriconazole were more than 80.0%.CONCLUSIONIt is feasible to give the patients the corresponding treatment in accordance with the clinical experimental test before the drug susceptibility testing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第13期3281-3283,共3页
Chinese Journal of Nosocomiology
基金
河南省教育厅科研基金(200813320010)
