摘要
通过探索合成路线,合成了硫康唑及其5个类似物。用药基法观察抗真菌活性,发现化合物Ⅰ、Ⅱ均比硫康唑的抗真菌活性强,尤以Ⅰ最为显著。
In order to search for a more potent and less toxic antifungal agent, five novel sulconazole analogues were synthesized by changing 1-imidazolyl and p-chlorobenzyl in sulconazole structure. The results of preliminary biological tests show that analogues Ⅰ and Ⅱ possess more potent antifungal activities and wider antifungal spectra than sulconazole.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第2期156-159,共4页
Academic Journal of Second Military Medical University
关键词
硫康唑
合成
抗真菌药
sulconazole
synthesis
antifungal agent
