摘要
目的检测分化抑制因子1(Id-1)在肝细胞肝癌组织中和正常肝组织中的表达情况,了解Id-1与肝细胞肝癌患者预后关系。方法对获得的19例肝细胞肝癌组织标本和8例正常肝组织进行免疫组织化学染色,并对染色结果进行分级。借助SPSS软件,分析肝细胞肝癌组织标本与正常肝组织标本中的Id-1表达强度区别,Id-1与甲胎蛋白(AFP)相关性,及Id-1表达强度与肝癌患者预后之间的关系。结果免疫组织化学染色结果显示所有标本均表达为阳性,其中3例(+),7例(++),10例(+++)7例(++++),肝细胞肝癌组织标本与正常肝组织标本差异有统计学意义(P<0.05);Id-1表达与血液中AFP水平相关不显著(r=-0.121,P=0.621);Spearman等级相关分析显示患者生存时间与Id-1表达呈负相关(r=-0.567,P=0.011)。结论 Id-1在肝癌组织中表达增高,Id-1表达水平与生存时间呈负相关,但和AFP无明显相关。
Objective To investigate the expression of inhibitor of differentiation-1（Id-1） in hepatoma tissues and normal liver tissues,and to analyze the relationship between Id-1 and prognosis of hepatoma.Methods The cancer tissues from 19 liver cancer patients and 9 normal liver tissues were graded with immunohistochemical staining.The difference of Id-1 expression between hepatoma tissues and normal liver tissues,the correlation of Id-1 and AFP,the relationship between Id-1 and prognosis of hepatoma were analyzed.Result All samples were positive in immunohistochemical staining,including 3 samples graded ＋,7 ＋＋,10 ＋＋＋,and 7 ＋＋＋＋.There was significant statistical difference in staining grade between hepatoma tissues and normal liver tissues（P〈0.05）,while no significant statistical difference was found between the Id-1 expression and AFP（r=-0.121,P=0.621）.Spearman＇s Rank Correlation Analysis indicated there was a significant negative correlation between survival time and Id-1 expression.Conclusion The expression of Id-1 is high in hepatoma and is negatively correlated with survival time,and is not correlated with AFP.
出处
《华西医学》
CAS
2013年第6期871-874,共4页
West China Medical Journal
关键词
分化抑制因子1
肝癌
预后
Inhibitor of differentiation-1
Hepatoma
Prognosis
