摘要
目的观察妊娠12周和24周的妊娠糖尿病和糖尿病合并妊娠妇女,FT3、FT4和TSH的变化,及各组人群在妊娠过程中甲状腺抗体的变化。方法对2010～2012年在吉林市中心医院妇产科、内分泌科门诊及病房就诊的妊娠妇女(糖尿病和妊娠糖尿病),共184名,在G12和G24分别测FT3、FT4、TSH、TPO、TG-ab。结果 1型糖尿病31例:2例甲减,3例亚临床甲减,占16.13%(5/31),4例甲状腺抗体阳性,占13.90%(4/31),其中1例产后甲状腺炎。2型糖尿病53例:1例亚临床甲减,占1.89%(1/51);1例甲亢,占1.89%(1/51);2例抗体阳性,占3.92%(2/53)。其中1例患产后甲状腺炎,占1.89%(1/51);2例糖尿病酮症酸中毒,其中1例,低T3综合征,后来引产。妊娠糖尿病49例:1例亚临床甲减,占2.04%(1/49);4例抗体阳性,占8.16%(4/49);1例糖尿病酮症酸中毒,死胎引产,其中1例产后甲状腺炎,占2.04%(1/49)。健康对照组51例:抗体阳性3例,占5.88%(3/51)。结论 1型糖尿病亚临床甲减发生率高;FT4G12时高于G24;既往无糖尿病病史,但有流产、死胎病史的患者有血糖高的原因;甲状腺抗体阳性的患者发生产后甲状腺炎的可能性大。
Objective Observe thyroid function and antibody changes in gestational diabetes mellitus and pregestational diabetes mellitus in the 12 weeks and the 24 weeks.Method A total of gestational women were divided into 3 groups,type 1 diabets,type 2 diabets,gestational diabetes mellitus,heathy control.In the G12 and the G24 check FT3,FT4,TSH,TPO,TG-ab.Results Incidence of subclinical hypothyroidism in the type 1 pregestational diabetes mellitus was higher.The leave of FT4 was higher in G12 than in G24.The patients with the medical history of misbirth or stillborn foetus had high blood glucose.It was possible that thyroid antibody positive patients occurred postpartum thyroiditis.Conclusion Incidence of subclinical hypothyroidism in type 1 pregestational diabetes mellitus was higher.The leave of FT4 was higher in G12 than in G24.The patients with the medical history of misbirth or stillborn foetus had the reason of high blood glucose.It was more possible that thyroid antibody positive patients occurred postpartum thyroiditis.
出处
《中国地方病防治》
2013年第3期232-233,共2页
Chinese Journal of Control of Endemic Diseases
关键词
妊娠糖尿病
糖尿病合并妊娠
甲状腺功能
Gestational diabetes mellitus
Pregestational diabetes mellitus
Thyroid function
