摘要
[目的]探讨肠癌患者血清巨噬细胞抑制因子-1(MIC-1)、神经肽Y(NPY)的表达及其与患者食欲减退的相关性。[方法]采用ELISA法测定34例晚期肠癌患者3个月前后血清MIC-1、NPY的表达,并进行食欲评分和体质指数计算。[结果]研究前34例患者MIC-1、NPY水平分别为(947.55±82.83)、(118.59±8.55)pg/ml;随访3个月后有6例患者死亡,余28例患者MIC-1水平升高为(1195.09±122.32)pg/ml,NPY水平下降至(99.20±7.33)pg/ml;前、后比较均差异有统计学意义(P<0.01)。3个月后食欲评分及体质指数均较研究前下降;食欲评分及体质指数与血清MIC-1呈显著负相关,与NPY呈显著正相关(均P<0.01)。[结论]晚期肠癌患者血清MIC-1表达升高而NPY表达下降,两者与食欲评分及体质指数的下降密切相关,是导致晚期肠癌患者食欲减退和体质量下降的原因之一。
[-Objective]To investigate the expression of MIC-1 in serum samples of colorectal cancer pa- tients and the correlation with the loss of appetite, [Methods]The expression of MIC-1 and NPY was de- tected by using the ELISA method in 34 advanced colorectal cancer patients＇ serum samples before and af- ter 3 months. And the appetite ratings and body mass index were calculated. [,Results]The expression of MIC-1 and NPY in 34 cases before the study was （947.55 ± 82.83）, （118. 59 ± 8.55） pg/ml respective- ly. After 3 months, 6 patients died. The MIC-1 levels elevated to （1 195.09± 122.32）pg/ml and the NPY levels decreased to （99.20±7.33）pg/ml remarkably （P〈0.01）. After 3 months , the appetite score and body mass index reduced, and the decreased levels was negatively correlated with serum MIC-1 and posi- tively correlated with serum NPY（P〈0.01）. [Conclusions] The expression of serum MIC-1 increased and NPY decreased in patients with advanced colorectal cancer. Both were closely related with the declined ap- petite ratings and body mass index, which might be one of the reasons to cause anorexia and weight loss in advanced colorectal cancer patients.
出处
《中国中西医结合消化杂志》
CAS
2013年第6期287-289,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
湖南省科技计划项目(No:2009sk3068)
关键词
肠肿瘤
巨噬细胞抑制因子-1
神经肽Y
食欲
colorectal cancer
macrophage inhibitory gytokine-l
neuropeptide Y
appetite
