摘要
目的观察替吉奥胶囊(S-1)单药用于老年胃癌患者术后辅助化疗的疗效及不良反应。方法 52例D2根治术后老年胃癌患者随机分为:治疗组(n=26)应用S-1单药辅助化疗(S-1 40～60mg口服,每天2次,d1～d28,6周为1周期),对照组(n=26)给予FOLFOX 4方案辅助化疗(奥沙利铂85mg/m2静滴,d1;亚叶酸钙200mg/m2静滴2h,d1～d2;氟尿嘧啶400mg/m2静滴,d1～d2;后续氟尿嘧啶600mg/m2持续静脉泵入22h,d1～d2,14天为1周期)。观察两组患者的1年、2年生存率及无复发生存率和不良反应情况。结果两组患者均完成6个月的辅助化疗,治疗组与对照组的1年生存率分别为69.23%和61.54%(P>0.05),1年无复发生存率分别为53.85%和57.69%(P>0.05);治疗组与对照组的2年生存率分别为34.62%和38.46%(P>0.05),2年无复发生存率分别为30.77%和23.08%(P>0.05)。治疗组的恶心呕吐、腹泻等消化道反应及周围神经毒性的发生率较对照组明显降低(P<0.05)。结论老年胃癌患者D2根治术后接受S-1单药辅助化疗的疗效不亚于FOLFOX 4方案联合化疗,毒副反应低,患者依从性好。
Objective To evaluate the efficacy and toxicity of S-1 for elderly patients with gastric cancer after radical surger- y. Methods After D2 radical surgery, 52 cases of elderly gastric cancer were divided into 2 groups randomly. Twenty-six cases were treated by S-1 （ S-1 40-60mg po, twice a day, d1 -d2s, 6 weeks was one cycle） as treatment group. The another 26 cases were treated by FOLFOX 4 （ oxaliplatin 85 mg/m2 iv, d1 ; calcium folinatc 200mg/m2, iv 2h, d1 -d2 ; 5-FU 400 mg/m2 iv, d1 -d2 ; 5-FU 600 mg/m2, civ 22h, d1 -d2,14 days was one cycle）as control group. Curative effects and toxicities were compared between the two groups in the follow- ing 2 years. Results All 52 patients were received 6 months＇ adjuvant chemotherapy. The 1-year survival rates in treatment and con- trol group was 69. 23% and 61.54% ,respectively（ P 〉 0. 05）. The 1-year relapse-free survival rates in two groups was 53.85% and 57.69% , respectively （P 〉 O. 05 ）. The 2-year survival rates in treatment and control group was 34. 62% and 38.46% , respectively（ P 〉0. 05）. The 2-year relapse-free survival rates in two groups was 30. 77% and 23.08% ,respectively（P 〉0. 05）. Incidence rates of nausea, emesis, diarrhea and PN toxicity were remarkably lower in treatment group than those in control group（ P 〈 0. 05 ）. Conclu- sion After D2 radical surgery, curative effects of S-1 is similar to FOLFOX 4 for elderly gastric cancer patients and S-1 has less toxici- ties.
出处
《临床肿瘤学杂志》
CAS
2013年第6期535-538,共4页
Chinese Clinical Oncology
