摘要
目的探讨不同年龄段冠心病患者的临床特点及相关的影响因素。方法采用回顾性研究,选择2007—2008年于我院冠状动脉造影并行介入治疗的冠心病患者340例,其中老年患者(老年组)210例,中青年患者(中青年组)130例。对两组患者的临床资料、实验室检查指标、冠心病的影响因素、冠状动脉病变情况及介入治疗后安全性,进行单因素分析。对单因素分析差异有统计学意义的因素带入多元线性回归,分析相关影响因素。结果(1)老年组与中青年组性别构成比较,差异有统计学意义(P<0.05)。(2)老年组患者的肌酐(Cr)、血浆凝血酶原时间(PT)、纤维蛋白原(FIB)水平高于中青年组,谷氨酰转肽酶(GGT)、三酰甘油(TG)、同型半胱氨酸(Hcy)、血小板计数(PLT)水平低于中青年组,且差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,Hcy、FIB是冠心病的危险因素。(3)老年组三支病变者发生率较中青年组高,差异有统计学意义(P<0.05)。临床不同表现类型在老年组及中青年组间比较,差异无统计学意义(P>0.05)。老年组患者冠状动脉造影术后总的不良事件发生率较中青年组增多,其中出血、心律失常、心源性休克的发生率也均较中青年组高,差异有统计学意义(均P<0.05)。结论老年冠心病患者与中青年患者在临床实验室指标上及临床预后方面存在差异,提示在临床治疗冠心病过程中治疗方案应存在一定差异。
Objective To investigate the clinical characteristics and influencing factors between different age patientswith coronary artery disease （ CAD） . Methods 330 CAD patients underwent coronary angiogram in our hospital from 2007 to2008were selected, including 210 cases of elder patients （ elder group） and 130 cases of young and middle aged patients（young and middle aged group） . Clinical data,laboratory indexes,influencing factors of CAD,stenosis of coronary artery andthe safety of intervention were given single factor analysis. And then multiple linear regression analysis was conducted on factorswith statistical significance in single factor analysis. Results （1 ） The sex ratio between the elder group and young and middleaged group showed statistically significant difference （P 〈0. 05） . （2） The Cr, PT, FIB in the elder group were significantlyhigher than the young and middle aged group,but GGT,TG,Hey and PLT were significantly lower than the young and middleaged group （P 〈0. 05） . Multiple factor regression analysis showed that Hey and FIB were risk factors for CAD. （3） The inci-dence of triple vessel disease in the elder group was significantly higher than that of the young and middle aged group （ P 〈0. 05 ）. Clinical characteristics between the two groups showed no statistically significant difference （ P 〉 0. 05 ） . The adverse e-vents in the elder group were more than those in the young and middle aged group,including bleeding,arrhythmia and cardio-genic shock （ all P 〈 0. 05 ） . Conclusion There were significant difference between different age patients with CAD in the clini-cal laboratory and clinical prognosis. It is suggested that the treatment should be different for CAD between the elderly and theyoung,middle - aged patients with CAD.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第18期2082-2084,共3页
Chinese General Practice
关键词
冠心病
冠状动脉造影
老年人
中青年人
Coronary artery disease； Coronary angioplasty； Elderly； Middle age and youth
