摘要
目的:探讨结肠癌转移相关基因1(MACC1)及肝细胞生长因子受体(c-Met)在肾盂癌中的表达及其与肾盂癌发生、发展、浸润转移的关系。方法:采用免疫组织化学染色法检测73例肾盂癌组织及20例癌旁正常组织中MACC1和c-Met的表达情况,并结合临床病理因素进行相关分析。结果:在肾盂癌组织中MACC1和c-Met的高表达率均明显高于正常肾盂黏膜组织(P<0.05)。MACC1和c-Met的高表达与患者性别、年龄、病理分级、吸烟和尿脱落细胞学检查结果无关,而与病理分期相关(P<0.05)。肾盂癌中MACC1的高表达与c-Met的高表达呈正相关(r=0.450,P<0.01)。结论:MACC1和c-Met的异常高表达可能与肾盂癌的发生、发展及浸润转移密切相关,联合检测可作为判断肾盂癌生物学行为的重要指标。
Objective： To investigate the expressions of metastasis-associated in colon cancer 1 （MACC1） and hepatocyte growth factor receptor （c-Met） in renal pelvic carcinoma, and to demonstrate their relationship with the occurrence, development and metastasis of renal pelvic carcinoma. Methods： The expressions of MACC1 and c-Met in 20 cases of normal mucosa and 73 cases of renal pelvic carcinoma were detected by immnnohistochemistry, based on which the clinical pathological features were analyzed. Results： The high expressions of MACC1 and c-Met were significantly higher in renal pelvic carcinoma than that in normal mucosa of renal pelvis （P〈0.05）. The high expressions of MACC 1 and c-Met were significantly related to differential pathological stage （P〈0.05）, but not with sex, age, pathological degree, smoking and urine eytology （P〉0.05）. A positive correlation was found between the high expressions of MACC1 and c-Met in renal pelvic carcinoma （r=0.450, P〈0.01）. Conclusion： The high-expression of MACC 1 and c-Met may play an important role in the development, progression and metastasis of renal pelvic carcinoma. The combined detection of MACC 1 and c-Met can be used to determine the biological behavior and prognosis of renal pelvic carcinoma.
出处
《天津医科大学学报》
2013年第4期290-293,共4页
Journal of Tianjin Medical University
基金
天津市科委抗癌重大专项课题基金资助(12ZCDZSY16600)
