摘要
目的评价中药药浴联合他克莫司软膏外用治疗儿童特应性皮炎的临床疗效及安全性。方法本试验采用随机、单盲、阳性平行对照试验将45例儿童患者采用随机数字表分成治疗组和对照组。治疗组23例,对照组22例。治疗组采用中药药浴治疗联合外用0.03%他克莫司软膏外用,1次/d。对照组单用0.03%他克莫司软膏外用,1次/d,疗程均为4周。随访3个月。结果 4周疗程结束后,2组间有效率差异无统计学意义(χ2=5.148,P<0.05)。2组初诊时SCORAD积分值比较差异无统计学意义(t=0.557,P>0.05),治疗4周后SCORAD积分值比较差异具有统计学意义(χ2=5.148,P<0.05))。结论中药药浴联合0.03%他克莫司软膏较单用0.03%他克莫司软膏治疗特应性皮炎疗效较优,复发率低,安全性好,值得临床推广。
Objective To evaluate clinical efficacy and safety of Chinese medicine bath combined with tacrolimus 6intment topical treatment of children with atopic dermatitis （AD）. Methods This trial was a randomized, single-blind, positive parallel controUed trial of 45 pediatric patients using a random number table divided into treatment group and control group. Treatment group included 23 patients and control group included 22 cases. Treatment group was treated with Chinese medicine bath combination with topical 0.03% tacrolimus the Secretary ointment, once a day. Control group was treated with 0.03% tacrolimus ointment, once a day. In both group treatment couse is four weeks. The patients were followed up for three months. Results After four weeks of treatment, the efficiency differences between the two groups was statistically significant （x2 = 3.794, P〉0.05）. SCORAD integral value in the two groups at diagnosis showed no statistically significant difference （t = 0.557, P〉 0.05）, SCORAD integral value after four weeks of treatment showed statistically significant difference （u=-2A11, P〈O.05）. Conclusion The Chinese medicine bath combined with 0.03% tacrolimus ointment than single with 0.03% tacrolimus atopic secretary ointment for the treatment of AD, the recurrence rate is low, security is good and worthy of clinical.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2013年第3期164-166,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
关键词
中药药浴治疗
他克莫司软膏
特应性皮炎
临床试验
Chinese medicine bath treatment
Tacrolimus ointment
Atopic dermatitis
Clinical trials
