摘要
目的比较多西他赛单药周化疗方案与三周化疗方案治疗老年晚期非小细胞肺癌的临床疗效及毒副作用。方法选取2008年1月—2011年3月我院住院的老年晚期非小细胞肺癌患者75例,按均衡原则依抽签法随机分为两组,对照组37例和治疗组38例。对照组患者接受多西他赛三周化疗方案,70 mg/m2,d1,21 d重复1次,共2个周期;治疗组患者接受多西他赛周化疗方案,35 mg/m2,d1、8,21 d重复1次,共2个周期。对比两组治疗效果和毒副作用发生情况。结果治疗后对照组部分缓解11例,稳定16例,进展10例。治疗组部分缓解12例,稳定16例,进展10例;两组治疗效果比较,差异无统计学意义(u=0.045,P>0.05)。对照组Ⅲ～Ⅳ度白细胞计数减少、粒细胞计数减少、恶心呕吐发生率分别为29例(78%)、30例(81%)、11例(30%),治疗组分别为2例(5%)、3例(8%)、3例(8%),差异均有统计学意义(χ2值分别为38.37、37.84、4.54,P<0.05)。结论对于老年晚期非小细胞肺癌患者,多西他赛单药周化疗方案疗效与三周化疗方案类似,且毒副作用更轻。
Objective To compare the clinical and side effects of 1 - week regimens of docetaxel chemotherapy with those of 3 - week regimens on elderly advanced non - small cell lung cancers （NSCLC）. Methods Seventy - five NSCLC pa-tients admitted to this hospital from January 2008 to March 2011 were divided, according to the homeostatic principle, into groups therapy （38） and control （37）. Control group were given 3-week regimens of doeetaxel, 70 mg/m^2, day 1, repeated on day 21, totally 2 cycles; treatment group given regimens of docetaxel, 35 mg/m^2, days 1, 8, repeated on days 21, totally 2 weeks. The therapy effects and side effects were compared between 2 groups. Results In control group, 11 patients had par-tial remission, 16 had stable conditions, 10 had progression; in therapy group, 12, 16, 10, respectively. There was not sig-nificant difference between 2 groups （ u = 0. 045, P 〉 0. 05 ）. In control group, 29 patients （78%） had Ⅲ-Ⅳ degree white blood cell decrease, 30 （81%） had neutrophil count decrease, incidence of nausea and vomiting was 30% （11 cases） ; in therapy group 2 （5%）, 3 （8%）, 3 （ 8% ）, respectively, the difference was significant （ X^2 = 38.37, 37.84, 4. 54, P 〈 0. 05）. Conclusion 1 - week regimens of docetaxel chemotherapy are similar to 3 - week regimens for elderly advanced NSCLC, with lower side effects.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第17期2039-2041,共3页
Chinese General Practice
关键词
癌
非小细胞肺
多西他赛
抗肿瘤联合化疗方案
毒副作用
Carcinoma, non - small - cell lung
Docetaxel
Antineoplastic combined chemotherapy protocols
Tox-icities
