摘要
目的探讨立体定向脑内核团毁损术及DBS治疗帕金森病的临床疗效。方法 50例PD患者均在CT/MRI定位下立体定向手术,45例行核团射频毁损术,5例PD DBS均选取STN为手术靶点。术前、术后1月进行UPDRS和ADL的评分,比较手术前后评分的变化和症状改善率。结果射频毁损术及DBS术后短期效果均满意,显效44例(88%),有效6例(12%),总有效率100%。术后1月的UPDRS与ADL评分较术前均明显减少(P<0.05,P<0.01),术后无明显并发症;随诊射频毁损者复发率8例(17.8%),DBS者无复发。结论立体定向脑内核团毁损及DBS术治疗帕金森病疗效显著。
Objective To explore the clinical efficacy of stereotactic intracerebral nucleus lesion and deep electrical stimulation（DBS）in the treatment of Parkinson＇s disease（PD）.Methods 50 cases of PD patients were applied stereotactic surgery in the CT/MRI.45 of patients were lesioned by radiofrequency ablation and 5 of cases were administrated DBS in subthalamic nucleus（STN）.UPDRS motor and ADL scores were assessed before and after one month surgery,and the changes of UPDRS and ADL scores and clinical efficacy were compared.Results The short-term effects after radiofrequency ablation and DBS were both satisfied,and the total efficiency was 100% with the remarkable result in 44 cases（88%）and the effective result in 6 cases（12%）.The score of UPDRS and ADL decreased significantly compared with the preoperative after a month（P 0.05,P0.01）,and none complication occurred.The recurrence rate was 8 cases（17.8%）by followed up and none patient of DBS recured.Conclusion The curative efficacy of stereotactic intracerebral nucleus damage and DBS is good in treatment of PD patients.
出处
《济宁医学院学报》
2013年第3期185-187,共3页
Journal of Jining Medical University
关键词
帕金森病
射频毁损术
脑深部电刺激术
Parkinson＇s disease
Radiofrequency ablation
Deep brain stimulation surgery
