摘要
目的探讨滇南小耳猪同种原位心肺联合移植手术体外循环管理的有效方法.方法 2009年1月至2010年3月对14只实验用封闭群滇南小耳猪进行心肺联合移植的实验研究.改进心肺灌注液和灌注方法,采用浅低温和中度低温体外循环,应用常规超滤与改良超滤技术,行多指标监测和临床观察.结果体外循环过程平稳,供体心肺保护好,7例手术成功,6例成功复跳,获得短期存活,达到研究目的.结论合理选择供体心肺保护液,改进供体心腔减压方法,良好的体外循环管理,减轻再灌注损伤和积极保护心肺功能是成功进行小耳猪原位心肺联合移植手术的关键.
Objective To explore an effective management method for extracorporeal circulation on combined heart-lung transplantation of Yunnan miniature pigs. Methods 14 Ynnnan miniature pigs were researched from 2009 January to 2010 March. In the extracorporeal circulation management, the ardiopulmonary perfusion and perfusion method were improved, shallow low and moderate hypothermic extracorporeal circulation was used, conventional ultrafiltration combined with modified ultrafiltration technology was applied, and multiple clinical indexes were monitored and observed. Results Extracorporeal circulation process was stable, and the donor heart and lung were kept good. 7 cases were operated successfully, and 6 cases were resuscitated successfully, which have short-term survival and achieved the research goal. Conclusion Rational choice of cardiopulmonary perfusion, improvement of the donor heart cavity decompression method, effective management of extracorporeal circulation, active alleviation of reperfusion injury and protection of the heart-lung function are critical factors for successfully orthotopic heart-lung transplantation on Yunnan miniature pig.
出处
《昆明医科大学学报》
CAS
2013年第5期37-42,共6页
Journal of Kunming Medical University
基金
云南省科技厅科技计划资助项目(2007CA005)
关键词
心肺联合移植
猪
体外循环
Combined heart-lung transplantation
Pig
Extracorporeal circulation
