摘要
目的:探讨11C-蛋氨酸PET-CT在复发胶质瘤的诊断以及放射治疗靶区规划中的临床价值。方法:对22例经头颅MRI增强扫描诊断为复发的胶质瘤患者行11C-蛋氨酸PET-CT检查,并通过开颅手术及活检获得病理;对12例病理证实复发病例利用PET-CT图像与MRI图像结合勾画靶区行三维适形放疗。结果:22例患者11C-蛋氨酸PET-CT显像真阳性16例,真阴性5例,假阳性1例,假阴性0例,灵敏度95.5%(21/22),特异性83.3%(5/6),假阳性率16.7%(1/6),假阴性率0,约登指数0.788;12例病理确诊复发者行三维适形放疗,4例靶区与T1WI增强区一致,2例靶区范围大于T1WI增强区,4例靶区范围小于T1WI增强区,2例靶区完全位于T1WI增强区之外。结论:11C-蛋氨酸PET-CT对诊断胶质瘤复发的准确性高,可用于MRI/CT诊断复发而临床尚不确诊病例的诊断;并能明显优化胶质瘤复发患者的放疗计划。
Objective： To study the clinical value of 11C-MET PET-CT in the diagnosis of recurren! glioma and in plan- ning radiation therapy target. Method： 11C-MET PET-CT examination was used in 22 glioma patients wilh cranial MRI en- hanced scan diagnosed recurrence, pathological diagnosis ohtained hy eraniotumy and biopsy, the three-dimensional conformal radiolherapy target was sketched using the combination of PET-CT images and MR images in 12 eases with pathologically confirmed recurrence. Results： PET-CT imaging of 22 patients with HC-MET： true positive 16 cases, true negative 5 cases, ihlse positive I case and no false negative cases, the sensitivity was 95.5%（21/22）, the specificity was 83.3%（5/6）, the false- positive rate was 16.7%（1/6）, the false-negative rate was 0, Youden index 0.788：12 patients with histologically eonfirmed re- currence were given the three-dimensional conformal radiotherapy, target range of 4 cases was consistent with T^WI enhanced region, 2 cases was greater than T1WI enhanced region, four cases was less than T1WI enhanced region, the target range of 2 eases located entirely outside %WI enhaneed region. Conclusion： HC-MET PET-CT has a high accuracy in the diagnosis of gliomu recurrenee, can he used in cases of MRI/CT diagnosis of recurrent, but the clinical diagnosis is not vet confirmed, and can obviously optimize radiotherapy planning in patients with glionm recurrence.
出处
《中国临床医学影像杂志》
CAS
2013年第6期385-388,共4页
Journal of China Clinic Medical Imaging
